전신과민성 식품 알레르기 마우스 모델에서의 도두(刀豆) 추출물의 항염 효과
Anti-inflammatory Effects of Canavaliae Semen(Canavalia gladiate) Extracts
양원경, 박양춘, 김한영, 김근회, 노성수, 김승형,
소속 상세정보
양원경 ( Yang Won-Kyung )
대전대학교 한의과대학 폐계내과학교실
박양춘 ( Park Yang-Chun )
대전대학교 한의과대학 폐계내과학교실
김한영 ( Kim Han-Young )
애경중앙연구소
김근회 ( Kim Kun-Hoae )
애경중앙연구소
노성수 ( Roh Seong-Soo )
대구한의대학교 한의과대학
김승형 ( Kim Seung-Hyung )
대전대학교 동서생명과학연구원
Abstract
Objective : An allergy to peanuts is a major cause of fatal food-induced anaphylaxis, with food allergies becoming an increasingly important health research issue. Food allergy as clinical entity has been recongnized for many years, although there is yet no general concord as to the incidence of this symptom.
Methods : This study was undertaken to verify the effect of seeds of Canavalia gladiata (Jacq.) DC. extract (CGE) on the inhibition of allergic reactions using a cholera toxin and peanut extract-immunized food allergy mouse model. We determine whether the changes in rectal temperature were related to energy consumption owing to heat production in the body. Mast cell distribution and degranulation in the dermis and epidermis were observed with an optical microscope. Subsequently, Ara h1 levels in serum and interleukin (IL)-4, IL-10, and IFN-γlevels in cultured supernatants of splenocytes were measured.
Results : CGE treatment significantly attenuated the secretion of the Ara h1 antibody in serum and splenocytes. Ara h 1 was undetected in the cholera toxin and peanut extract-immunized food allergy mouse model. Improvement in ear tissue inflammation symptoms was the CGE experimental group. In the control group and peanut extract control group, the expression of mast cells was higher, whereas that in the CGE experimental group was significantly lower.
Conclusion : CGE causes suppression in a food allergy mouse model via the inhibition of Ara h1 secretion, and might be useful for developing functional health foods.
키워드
anti-allergy; Canavaliae Semen; Canavalia gladiata; cholera toxin; food allergy; immunogenicity; Systemic Anaphylaxis
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