알코올을 투여한 흰쥐의 알코올 대사에 미치는 한약재 혼합추출물의 영향
The effect of herbal mixture on alcohol metabolism in Sprague Dawley rats
정미진, 김소영, 도은주, 윤종국, 김대익, 한경수, 김미려,
소속 상세정보
정미진 ( Jeong Mi-Jin )
대구한의대학교 한의과대학 본초약리학교실
김소영 ( Kim So-Young )
대구한의대학교 한의과대학 본초약리학교실
도은주 ( Do Eun-Ju )
(재)대구테크노파크 한방산업지원센터
윤종국 ( Yun Jong-Kuk )
(재)대구테크노파크 한방산업지원센터
김대익 ( Kim Dae-Ik )
(재)대구테크노파크바이오산업지원센터
한경수 ( Han Kyung-Soo )
이전한방연구회
김미려 ( Kim Mi-Ryeo )
대구한의대학교 한의과대학 본초약리학교실
Abstract
Objectives : Alcohol hangover is a common phenomenon which basically occurs after heavy drinking. Moreover, heavy alcohol consumption leads to acute and chronic diseases. We investigated the effect of herbal mixture (SJ) on alcohol metabolism in serum or/and liver.
Methods : 5W-old Sprague Dawley rats were used for the study. To overnight fasted rats, 0.9% saline or SJ extract was administrated per os before alcohol treatment. Then, 40% alcohol was orally administrated to all rats in 30 mins. Ethanol, acetaldehyde concentrations, alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH) activities were measured by assay kits. Aspartate aminotransferase (AST) and alanine transaminase (ALT) were measured by analyzer.
Results : Ethanol and acetaldehyde concentrations lowered in SJ groups compared with CON group. Especially, acetaldehyde concentration significantly decreased in SJ groups compared with CON group. AST and ALT levels tended to increase in SJ groups compared with CON group but there was no significant difference between CON group and SJ groups. ADH activity in serum was higher in SJ groups than CON group but no significant difference in liver. ALDH activity in both serum and liver showed significantly increased in SJ groups compared with CON group.
Conclusions : Treatment of SJ extract showed not only reducing concentration of alcohol and acetaldehyde but also increasing activities of ADH and ALDH. These results suggest SJ may influence in alcohol metabolism via control of metabolic enzyme activities and metabolite. Therefore, SJ, herbal mixture, might have a function of preventing hangover after drinking alcohol.
키워드
Alcohol metabolism; ethanol; acetaldehyde; ADH; ALDH
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