보중익기탕(補中益氣湯)이 streptozotocin 유발 당뇨병성 위부전마비백서에 미치는 영향
The Effects of Bojungikgi-tang on Streptozotocin-induced Diabetic Gastroparesis Rat Model
강윤미, 김효정, 박윤범, 정찬문, 함성호, 양웅모, 안효진,
소속 상세정보
강윤미 ( Kang Yun-Mi )
상지대학교 한의과대학 약리학교실
김효정 ( Kim Hyo-Jung )
상지대학교 한의과대학 약리학교실
박윤범 ( Park Yun-Beom )
한국한의약진흥원 한약재표준화팀
정찬문 ( Jeong Chan-Mun )
한국한의약진흥원 한약재표준화팀
함성호 ( Ham Seong-Ho )
한국한의약진흥원 한약재표준화팀
양웅모 ( Yang Woong-Mo )
경희대학교 한의과대학 융합의과학교실
안효진 ( An Hyo-Jin )
상지대학교 한의과대학 약리학교실
Abstract
Objective : Diabetic gastroparesis is a complication that is defined as delayed gastric emptying and upper gastrointestinal symptoms and often occurs in long-standing diabetic patients. Bojungikgi-tang (BJT) is a traditional oriental herbal formula that has long been used for the treatment of digestive disorders. The purpose of this study was to investigate the effects of BJT on streptozotocin (STZ)-induced diabetic gastroparesis rat model.
Methods : Sprague-Dawley (SD) male rats (250-270g) were divided into 13 groups including normal group, STZ- induced diabetic control group, BJT diet (7 various concentrations), and insulin-, glibenclamide-, metformin- treated group were used for the experiments for the comparison. Diabetic gastroparesis was induced by intraperitoneal injection of STZ. The water intake, food intake, body weights and fasting blood glucose levels were measured. After 4 weeks the animals were sacrificed and gastrin, leptin, insulin, hemoglobin A1C (HbA1c), lactate, lactate dehydrogenase (LDH), bilirubin, creatinine, albumin and lipid levels were evaluated.
Results : Intraperitoneal injection of BJT for 4 weeks resulted in increased levels of gastrin in blood and decreased leptin and lactate concentration in STZ-induced diabetic gastroparesis rat model. BJT did not affect insulin, fasting glucose, HbA1c, and lipid levels in STZ-induced diabetic gastroparesis rat model.
Conclusion : These results indicated that BJT would have protect effect on diabetic gastroparesis through the improvement effect of gastric motility and fatigue syndrome in STZ-induced diabetic rats. This study shows that BJT might be effective for treatment of diabetes and its complications such as gastroparesis.
키워드
Bojungikgi-tang; diabetes; diabetic gastroparesis; streptozotocin
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