해마경화를 동반한 난치성 측두엽 간질의 해마 신경원세포 조밀도 및 세포소실도
Hippocampal Neuronal Cell Density and Neuronal Cell Loss in Intractable Temporal Lobe Epilepsy with Hippocampal Sclerosis
김장성, 김정선, 허균, 조경기, 윤수한, 안영환, 주희재, 오명수, 심철, 서중석,
소속 상세정보
김장성 ( Kim Jang-Sung )
아주대학교 의과대학 신경과학교실
김정선 ( Kim Jung-Sun )
아주대학교 의과대학 병리학교실
허균 ( Huh Kyoon )
아주대학교 의과대학 신경과학교실
조경기 ( Cho Kyung-Gi )
아주대학교 의과대학 신경외과학교실
윤수한 ( Yoon Soo-Han )
아주대학교 의과대학 신경외과학교실
안영환 ( Ahn Young-Hwan )
아주대학교 의과대학 신경외과학교실
주희재 ( Joo Hee-Jae )
아주대학교 의과대학 병리학교실
오명수 ( Oh Myung-Soo )
아주대학교 의과대학 신경과학교실
심철 ( Sim Chul )
아주대학교 의과대학 병리학교실
서중석 ( Seo Joong-Seok )
국립과학수사연구소 법의학부
KMID : 0877219970010010085
Abstract
Purpose : Hippocampal sclerosis (HS) is the most common neuropathological condition encountered in temporal lobe epilepsy (TEL). The measurement of hippocampal neuronal cell density and neuronal cell loss was established as an essential process in understanding of the epileptogenesis of TLE. This study was designed for the purposes of establishment of morphometric data of HS in Korean TLE patients since such a study does not exist in Korean literature.
Method : In each 15 hippocampal slices from TLE patients and autopsied cases, the measurements were performed by modified Yale method.
Result : Mean cell density (/㎣) was 802 in CA1, 6999 in CA2, 2408 in CA3, 733 in CA4 62363 in granular layer (GL) and 73306 in total hippocampal area. Mean cell loss (%) was 91 in GA1, 56 in CA2, 74 in CA3, 86 in CA4, 71 in GL, and 71 in total area, respectively. These data are well below the measured value of those done in other countries, however. All cases showed hippocampal atrophy quantitatively defined as total area cell density below mean-two standard deflation.
Conclusion : This study describes the degree and patterns of hippocampal neuronal loss in Korean TLE patients. This morphometric data may subserve a reference value for future large scale studies
키워드
해마신경원세포조밀도 및 세포 소실도; 해마경화; 측두엽간질
Hippocampal neuronal cell density; Neuronal cell loss; Hippocampal sclerosis; Temporal lobe epilepsy
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