Sodium Valproate 복용후 발생한 Hyperammonemia 1례
A Case with Hyperammonemia due to Sodium Valproate
박민규, 이대희,
소속 상세정보
박민규 ( Park Min-Kyu )
고려대학교 의과대학 신경과학교실
이대희 ( Lee Dae-Hie )
고려대학교 의과대학 신경과학교실
KMID : 0877219970010010146
Abstract
A 35-year-old woman diagnosed as complex partial seizure tilth secondary generalization has been treated with sodium valproate for the last 2 years. Progressive impairment of consciousness to deep drowsy state without focal neurologlc signs hospitalized her and the following medical evaluation repealed hyperammonemia without hepatic cause. Hyperammonemia as well as her previously deteriorated consciousness was improved after the discontinuation of sodium valproate. Moreover her hepatic function, biliary system and urea cycle were perfectly normal. Therefore, we report a case of hyperammonemia which is due to 2-year-course of sodium valproate administration could be recovered with removal of the offending agent. This suggests that sodium valproate induced hyperammonemia and hepatic failure after sodium valproate treatment main haute 3 different biochemical basis.
키워드
인격변화; 복합부분 발작; 게쉬윈드 증후군
Complex partial seizure; Sodium valporate; Hyperammoninemia
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