해마경화를 동반한 난치성 측두엽 간질 환자의 해마내 신경원세포의 Dynorphin 면역반응 양상
Dynorphin-immunoreactivity Patterns of Hippocampus in Patients with Intractable Temporal Lobe Epilepsy with Hippocampal Sclerosis
김장성, 김정선, 주희재, 심철, 조경기, 허균, 서중석,
소속 상세정보
김장성 ( Kim Jang-Sung )
아주대학교 의과대학 신경과학교실
김정선 ( Kim Jung-Sun )
아주대학교 의과대학 병리학교실
주희재 ( Joo Hee-Jae )
아주대학교 의과대학 병리학교실
심철 ( Sim Chul )
아주대학교 의과대학 병리학교실
조경기 ( Cho Kyung-Gi )
아주대학교 의과대학 신경외과학교실
허균 ( Huh Kyoon )
아주대학교 의과대학 신경과학교실
서중석 ( Seo Joong-Seok )
국립과학수사연구소 법의학부
KMID : 0877219980020020121
Abstract
Background : Dynorphin (DYN) is one of neuropeptides widely distributed in primate brain. In human mesial temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS), DYN-immunoreactivity (DYNIR) band in inner molecular layer of hippocampal dentate gyrus (DGIML) is a well-known immunohistochemical feature, whereas DYNIR is present in axonal terminals of dentate granular neurons (DGNs) in normal hippocampus. We evaluated DYNIR patterns in resected hippocampal specimens of Korean TLE patients with HS.
Methods : Eleven hippocampal specimens resected from 11 intractable TLE patients tilth HS on MRI were available for immunohistochemical staining for dynorphin-A. Nine hippocampal specimens from autopsied controls were also evaluated for DYNIR. In either cases, we investigated patterns of DYNIR in neuronal fibers of all sectors. In hippocampus from CA1 to dentals gyrus.
Results : Five patterns of DYNIR were demonstrated as follows : 1) Pattern Ⅰ : Four crises showed a typical pattern with DYNIR band in DGIML without demonstrating immunoreactivity in any other region. 2) Pattern Ⅱ : Four closes demonstrated DYNIR in hilus as well as DGIML. 3) Pattern Ⅲ : In one case, DYNIR appeared in DGIML, hilus and CA3. 4) Pattern Ⅳ : In one, only hilus and CA3 were immunoreactive to dynorphin. 5) Pattern Ⅴ : The last one showed a combination of pattern Ⅲ and no DYNIR at the opposite blade of DG. In normal hippocampal specimen, DYNIR was shown in hilus and at stratum lucidum along CA3 region.
Conclusion : Previous studios have been emphasizing the typical pattern Ⅰ.However, the result of this study argues that patterns of DYNIR are variable in intractable TLE with HS.
키워드
측두엽간질; 해마경화; Dynorphin면역반응
Temporal lobe epilepsy; Hippocampal sclerosis; Dynorphin-immunoreactivity
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