West 증후군에서 Topiramate의 효과
Efficacy of Topiramate in West Syndrome
이인규, 김성구, 이란, 권영세, 이종화, 채종희, 김기중, 황용승,
소속 상세정보
이인규 ( Lee In-Kyu )
인하대학교 의과대학 소아과학교실
김성구 ( Kim Sung-Koo )
을지대학교 의과대학 소아과학교실
이란 ( Lee Ran )
서울대학교 의과대학 소아과학교실
권영세 ( Kwon Young-Se )
서울대학교 의과대학 소아과학교실
이종화 ( Lee Jong-Hwa )
서울대학교 의과대학 소아과학교실
채종희 ( Chae Jong-Hee )
서울대학교 의과대학 소아과학교실
김기중 ( Kim Ki-Joong )
서울대학교 의과대학 소아과학교실
황용승 ( Hwang Yong-Seung )
서울대학교 의과대학 소아과학교실
KMID : 0877220000040010027
Abstract
Purpose: The treatment of West syndrome is difficult since current antiepileptic drugs are rarely effective. The objective of this study is to evaluate the clinical efficacy of topiramate as add-on therapy in the refractory West Syndrome.
Methods: Nineteen children with refractory infantile spasms were included in this study. Topiramate was given as an initial dose of 25 mg per day in addition to the current antiepileptic drug (s). Dosage was increased by 25 mg every week until spasms were controlled, the maximal tolerable dose was reached, or the maximal dose of 25 mg/kg/day was achieved.
Results: Five (26.3%) subjects became seizure free and 7 (36.8%) achieved seizure frequency reduction more than 50%. No significant side effect of topiramate was noted.
Conclusion: Topiramate could be a promising therapy in the treatment of refractory West syndrome.
키워드
West 증후군
Topiramate; West syndrome; Topiramate
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