측두엽 간질에서 MRI상 나타난 해마의 손상과 이차성 전신성 발작과의 관계 : 정성적, 정량적 MRI 연구
The Relationship between Hippocampal Damage on MRI and Secondarily Generalized Tonic Clonic Seizures in Temporal Lobe Epilepsy : Quantitative and Qualitative MRI Study
김성은,
소속 상세정보
김성은 ( Kim Sung-Eun )
인제대학교 의과대학 부산백병원 신경과
KMID : 0877220010050020131
Abstract
Purpose: It has been suggested that recurrent seizures may cause the hippocampal formation (HF) damage in temporal lobe epilepsy (TLE). To evaluate whether secondarily generalized tonic clonic seizure (SGTC) is related to the degree of the HF damage on MRI we performed this study.
Methods: We found 42 patients with TLE who had HS on qualitative MRI from epilepsy database. They were divided into unilateral HS (UHS) and bilateral HS (BHS) on qualitative MRI by visual analysis. We performed HF volumetry in 20 and T2 relaxometry in 22 (17 patients were lateralized by quantitative MRI and ictal or interictal EEG).
Results: The frequency of status epilepticus and SGTCs in BHS were significantly higher than that in UHS (14% vs 3%, p<0.05 and 60% vs 6%, p<0.05 respectively). Of 17 patients who were lateralized, the frequency of SGTCs was significantly correlated to the ipsilateral (r=0.58, p<0.05) and contralateral (r=0.35, p<0.05) T2 relaxometry as well as inversely to the ipsilateral (r=-0.59, p<0.05) and contralateral (r=-0.52, p<0.05) HF volume.
Conclusions: BHS has the higher frequency of status epilepticus and SGTCs, and the frequency of SGTCs was related to the HF damage.
키워드
측두엽 간질; 해마 경화
Temporal lobe epilepsy; Hippocampal sclerosis; Hippocampal volumetry; Hippocampal T2 relaxometry; Secondarily generalized tonic clonic seizure
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