새로운 비선형 알고리듬을 이용한 간질발작의 예측에 관한 연구 - Non-linear Periodicity of Inter-Spike Intervals -
The Anticipation of Epileptic Seizures by Non-linear Periodicity of Inter-Spike Intervals
이향운, 홍승봉, 신원철, 손영민, 이운철, 김세용, 김승환,
소속 상세정보
이향운 ( Lee Hyang-Woon )
이화여자대학교 의과대학 신경과학교실
홍승봉 ( Hong Seung-Bong )
성균관대학교 의과대학 삼성서울병원 신경과학교실
신원철 ( Shin Won-Cheol )
성균관대학교 의과대학 삼성서울병원 신경과학교실
손영민 ( Shon Young-Min )
성균관대학교 의과대학 삼성서울병원 신경과학교실
이운철 ( Lee Woon-Chyul )
포항공과대학교 물리학과
김세용 ( Kim Sae-Yong )
포항공과대학교 물리학과
김승환 ( Kim Seung-Hwan )
포항공과대학교 물리학과
KMID : 0877220010050020142
Abstract
Purpose: To develop a fast and robust seizure anticipation program and test its usefulness in seizure prediction and localization of epileptic focus.
Methods: The video-EEG monitoring was performed in 20 epilepsy patients. The NPISI (Nonlinear Periodicity of Inter-Spike Intervals) of each channel and averaged NPISI of all channels were calculated in pre-ictal and ictal periods of 21 epileptic seizures. Seizure prediction times of NPISI in each channel and all channels were determined.
Results: There were eight mesial TLE, twelve neocortical epilepsies. The significantly reduced NPISI prior to seizure onset was observed in 20 seizures (95.2%) by NPISI of single EEG channel and in 14 seizures (66.7%) by the averaged NPISI of all channels. Time of seizure anticipation was 17.3+/-7.3 min by single channel NPISI and 14.0+/-6.0 min by all channel NPISI prior to the seizure onset. The earliest NPISI reduction was detected at electrodes concordant to the seizure focus in 6/20 (30.0%) seizures, electrodes adjacent to the focus in 5/20 (25.5%), mirror electrodes contralateral to the seizure focus in 4/20 (20.0%), and irrelevant electrodes to the focus in 5/20 (25.5%).
Conclusions: This study demonstrated that the reduction of NPISI could predict epileptic seizures long before clinical seizure onset. Although the earliest NPISI reduction was observed at or near to epileptic focus in most cases, pre-ictal changes of NPISI occurred far beyond the epileptic focus. These findings suggest that pre-ictal NPISI reduction may reflect a widespread facilitation of brain before the seizure onset.
키워드
비선형 뇌파분석; 시공간 관계
Nonlinear EEG analysis; NPISI (Nonlinear Periodicity of Inter-Spike Intervals); Preictal; Ictal; Spatiotem-poral relationship
원문 및 링크아웃 정보
등재저널 정보