고해상도 자기공명영상을 이용한 청소년기 근간대성 간질 환자의 뇌량 면적 측정
Measurement of Corpus Callosal Area in Juvenile Myoclonic Epilepsy Using High Resolution Magnetic Resonance Imaging
태우석, 홍승봉, 신원철, 이향운, 서대원, 이문향, 정균락, 변영태,
소속 상세정보
태우석 ( Tae Woo-Suk )
성균관대학교 의과대학 삼성서울병원 신경과학교실
홍승봉 ( Hong Seung-Bong )
성균관대학교 의과대학 삼성서울병원 신경과학교실
신원철 ( Shin Won-Cheol )
성균관대학교 의과대학 삼성서울병원 신경과학교실
이향운 ( Lee Hyang-Woon )
이화여자대학교 의과대학 신경과학교실
서대원 ( Seo Dae-Won )
성균관대학교 의과대학 삼성서울병원 신경과
이문향 ( Lee Mun-Hyang )
성균관대학교 의과대학 삼성서울병원 소아과학교실
정균락 ( Chong Kyun-Rak )
홍익대학교 정보대학원
변영태 ( Byun Young-Tae )
홍익대학교 정보대학원
KMID : 0877220010050020156
Abstract
Background: To investigate the change of corpus callosal area in juvenile myoclonic epilepsy (JME), the mid-sagittal areas of corpus callosum and its seven sub-regions were measured in JME patients and normal subjects.
Methods: Nineteen JME patients (22.6+/-5.0 year-old, 6 males, 13 females) and 19 normal controls (22.9+/-7.3 year-old, 6 males, 13 females) underwent 1.6 mm thickness whole brain SPGR MRI. Exact mid-sagittal image was obtained with image reconstruction and geometric correction. According to Witelson’s work, the area of corpus callosum was divided into 7 sub-regions (a1 to a7 from anterior to posterior) with a semi-automated method. In each sub-region, the pixel number was counted according to ROI definition. The whole cerebral volume was measured. The mid-sagittal cerebral area was measured by tracing inner surface of skull and basal cortical surface of the cerebrum except for corpus callosum and cerebellum. The difference of corpus callosum areas between JME patients and normal controls were tested by t-test and ANCOVA.
Results: There was no difference in sex [chi-square(1)=1.00, chi square] and age (p=0.941, Mann-Whitney U test). The areas of rostrum (p<0.001) and rostral body (p < or = 0.05) were significantly smaller in JME group by t-test and ANCOVA (adjusted by age and cerebral volume). Cerebral volume and mid-sagittal cerebral area were not different between JME and normal groups (p>0.25, t-test).
Conclusion: Rostrum and rostral body are significantly smaller in JME patients, which suggests frontal lobe abnormality in JME. This finding is consistent with previous studies reported structural and functional abnormalities of frontal lobe in JME.
키워드
청소년기 근간대성 간질; 뇌량; 자기공명영상; 면적 측정
Juvenile myclonic epilepsy; Corpus callosum; Magnetic resonance imaging; Area measurement
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