Carbamazepine에 의한 야뇨증 2례
Two Cases of Nocturnal Enuresis Associated with Carbamazepine
노영일, 문경래, 박영봉,
소속 상세정보
노영일 ( Rho Young-Il )
조선대학교 의과대학 소아과학교실
문경래 ( Moon Kyung-Rye )
조선대학교 의과대학 소아과학교실
박영봉 ( Park Yeong-Bong )
조선대학교 의과대학 소아과학교실
KMID : 0877220020060010057
Abstract
저자들은 carbamazepine 투여 후 빈뇨, 긴박뇨를 동반한 야뇨증이 발생하였으며, 원인을 찾기 위한 침습적인 검사를 하기 전에 약물의 중단과 약물을 대체하여 배뇨장애가 자연소실된 2례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Urinary voiding disorders owing to anticonvulsants medications have been reported rarely. I have recently seen 2 patients in whom carbamazepine (Tegretol) therapy was associated with nocturnal enuresis. The first patient was a 7-year-old boy in whom carbamazepine 150 mg twice a day (15 mg/kg, early morning plasma level 10 microgram/mL before the morning dose) was prescribed for control of complex partial seizure. Approximately 5 months after starting to take the drug he developed frequency of micturition and urgency. Soon followed by nocturnal enuresis. His development was normal. Sphincter control was complete at 3 years of age. Urinalysis was negative. Carbamazepine discontinued and within 1 week all urinary symptoms disappeared. Second patient was a 6-year-old girl in whom carbamazepine 100 mg twice a day (15 mg/kg, early morning plasma level 7.06 microgram/mL before the morning dose) was prescribed for control of simple partial seizure. Approximately 10 weeks after starting to take the drug he developed urgency, and then after 2 weeks followed by daily nocturnal enuresis. Her development was normal. Urinalysis was negative. Carbamazepine was changed to oxcarbazepine, and the patient’s urinary symptoms abated within 2 weeks disappeared and did not recur. The nocturnal enuresis in both patients can be attributed to carbamazepine;it appeared after 3-4 months of the start of treatment;during seizure-free period and disappeared on discontinuation of carbamazepine. The drug should be discontinued before any other invasive investigations are undertaken to clarify the cause of the urinary symptoms.
키워드
야뇨증
Nocturnal enuresis; Carbamazepine
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