Phenytoin에 의해 조기 발생한 단독적인 혈소판 감소증 1례
A Case of Phenytoin-Induced Early Onset Isolated Thrombocytopenia
윤영훈, 문경래, 노영일,
소속 상세정보
윤영훈 ( Yoon Young-Hun )
조선대학교 의과대학 소아과학교실
문경래 ( Moon Kyung-Rye )
조선대학교 의과대학 소아과학교실
노영일 ( Rho Young-Il )
조선대학교 의과대학 소아과학교실
KMID : 0877220020060010077
Abstract
저자들은 3세 1개월된 간질 중첩증 환아에서 phenytoin 단독 투여 2일 후에 단독적인 혈소판 감소증을 보이고 phenytoin중단 후 4일 째에 완전히 혈소판 수가 회복된 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Phenytoin is useful medication in patients with seizure disorders. Hematologic side effects of phenytoin treatment are rare. Especially, isolated thrombocytopenia is very rare. This condition is presumably the result of an immune-mediated process caused by antiplatelet antibodies induced by a drug as a hapten. Thrombocytopenia as a side effect of the phenytoin treatment usually has been reported in adults. It generally occurs at 2 to 4 weeks after initiation of therapy and resolved at 2 to 28 days after discontinuation of the phenytoin. In our case, the thrombocytopenia developed on the 2nd day of therapy and resolved on the 4th day after discontinuation of the phenytoin. We report a 3-year-old girl who developed reversible thrombocytopenia during the phenytoin treatment.
키워드
혈소판 감소증
Phenytoin; Thrombocytopenia;
원문 및 링크아웃 정보
등재저널 정보