난치성 소아 간질에서 케톤생성 식이요법이 혈중 지질 농도에 미치는 영향
Lipid Profiles in Patient With Ketogenic Diet for Intractable Childhood Epilepsy
김흥동, 박미정, 박중채,
소속 상세정보
김흥동 ( Kim Heung-Dong )
인제대학교 의과대학 상계백병원 소아과학교실
박미정 ( Park Mi-Jung )
인제대학교 의과대학 상계백병원 소아과
박중채 ( Park Jung-Chae )
소화아동병원 소아과
KMID : 0877220020060020124
Abstract
Purpose: Ketogenic diet has been frequently used in the treatment of intractable childhood epilepsy since proven strong antiepileptic effects. Because of prolonged maintenance of high fat diet, long-term side effects of hyperlipidemia and atherosclerosis has been concerned, but there are no sufficient data revealing lipid profile from ketogenic diet. This study is intended to investigate the changes of lipid profiles in patients with ketogenic diet.
Methods: Sixty-six children (0.8-14.7 yrs, mean age 4.6+/-3.6 yrs, 33 males and 33 females) with intractable epilepsy treated with the classic (4:1) ketogenic diet were studied at Inje University Sang-gye Paik Hospital, from January 1997 to July 2001. Follow-up period was more than 1year (range:1-2 yrs). Cholesterol, HDL-cholesterol and Triglyceride (TG) concentrations were measured at 1 day, 7 days, 6 months, 12 months, 18 months and 24 months, and LDL-cholesterol concentrations were measured.
Results: 1) Total cholesterol concentrations were significantly increased from 7 days to 24 months after ketogenic diet than that before ketogenic diet (p<0.05). 2) HDL-cholesterol concentrations were not significantly changed for 2 years. 3) LDL-cholesterol concentrations were significantly increased at 6 months (119.9 mg/dL, p<0.05), and 24 months (128.0 mg/dL, p<0.05). 4) TG concentrations were significantly increased at 7 days (164.9 mg/dL, p<0.05), 6 months (209.7 mg/dL, p<0.01), and 12 months (192.0 mg/dL, p<0.01), and were normalized at 18 months, 24 months.
Conclusion: Most of lipid profiles were significantly changed during ketogenic diet. Long-term complication for cardio-vascular diseases should be further investigated.
키워드
Ketogenic diet; lipid profiles; Intracable childhood epilepsy
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