신경외과에서의 수술전후 항경련제의 사용
Perioperative Use of Anticonvulsants in Neurosurgery
피지훈, 정천기,
소속 상세정보
피지훈 ( Phi Ji-Hoon )
서울대학교 의과대학 신경외과학교실
정천기 ( Chung Chun-Kee )
서울대학교 의과대학 신경외과학교실
KMID : 0877220030070010037
Abstract
The perioperative use of anticonvulsants in patients receiving craniotomy for various CNS diseases has been a routine practice in neurosurgery. However, there have been no unified evidence-based guidelines for the perioperative use of anticonvulsants. We searched for published studies related to this subject in MEDLINE and reviewed them. Several randomized controlled studies were regarded as more important because they could provide strong evidence.The conclusions are as follows. First, postoperative seizures are serious problems in neurosurgical practice and should be strictly controlled. Second, anticonvulsants could decrease the occurrence of postoperative seizures. Third, the therapeutic serum levels of anticonvulsants are of utmost importance in the prevention of postoperative seizures. Fourth, valproic acid has no advantage over phenytoin in the prevention of postoperative seizures.
키워드
Postoperative seizure;Anticonvulsants;Pheny-toin;Valproic acid
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