실험적 쥐 대뇌 피질이형성증의 발현과정에 있어 아포토시스의 역할
Role of Apoptosis in Development of Experimental Rat Cerebral Cortical Dysplasia
이윤진, 정천기,
소속 상세정보
이윤진 ( Lee Yun-Jin )
서울대학교 의과대학 신경외과학교실
정천기 ( Chung Chun-Kee )
서울대학교 의과대학 신경외과학교실
KMID : 0877220030070020101
Abstract
Microgyria is one type of cortical dysplasia with dyslaminations and anomalous cell densities, which could be produced experimentally. In a normal rat cortical development, overproduced neuroblasts gradually die by apoptosis. Thus, the diminished apoptosis may lead to the anomalous cell densities and dyslaminations. This study examined the ontogeny of cell densities in rat microgyria, in homotopic contralateral cortex and in control cortex. Multiple applications of cold probe (-70℃) on the right hemisphere in postnatal day (PN) 0 rat pups produced unilateral microgyria. Cell densities had decreased from PN 1 to 2 in microgyria, in the contralateral left hemisphere, and in the control cortex. From PN3 to PN10, while the cell density of the microgyria had increased (p<0.001), cell densities of the control and homotopic area continued to decrease. Apoptosis was greater in the microgyria than in the control and left hemisphere from PN1 to 3 and then remarkably decreased (p<0.001). These results suggest that the increased cell density in microgyria is not from decreased apoptosis, but probably caused by the increased proliferation or migration.
키워드
Microgyria;Apoptosis;Rat freezing model;Cortical dysplasia;Cell migration
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