난치성 소아 간질의 미주신경자극술 효과
Therapeutic Outcomes of Vagus Nerve Stimulation in Intractable Childhood Epilepsy
강훈철, 김흥동, 황용순, 박상근,
소속 상세정보
강훈철 ( Kang Hoon-Chul )
인제대학교 의과대학 상계백병원 소아과
김흥동 ( Kim Heung-Dong )
연세대학교 의과대학 소아과학교실
황용순 ( Hwang Yong-Soon )
인제대학교 의과대학 상계백병원 신경외과
박상근 ( Park Sang-Keun )
인제대학교 의과대학 상계백병원 신경외과
KMID : 0877220030070020118
Abstract
Purpose：This study is to evaluate the efficacy and safety of vagus nerve stimulation (VNS) in intractable childhood onset epilepsy by reviewing our experiences.
Mehthod：Involved in the study are five patients who underwent VNS from July 23th, 1999 and had been followed up over 12 months. We reviewed data prospectively collected with a focus on clinical features, therapeutic outcomes and safety, developmental progress, and EEG findings.
Results：Three patients were classified as Lennox-Gastaut syndrome. One patient of the two remaining patients had gelastic seizure caused by hypothalamic harmatoma, while the other patient had partial seizure with secondary generalization. Among the 5 patients, one patient showed a seizure frequency reduction rate of about 50% from baseline in 3 months after VNS implantation and more than 90% in 12 months, 2 patients of about 50% in 3 months and of about 75% in 12 months, but the other two patients didn´t show any change in seizure frequency. Side effects such as hoarseness, dyspnea during sleep and wound infection could be controlled simply through the adjustment of output current or wound revision. However, efficacy in cognitive function and EEG findings was not satisfactory.
Conclusions：VNS might be an effective adjunctive therapy for intractable childhood epilepsy and transient side effects can be controlled without discontinuation of VNS therapy.
키워드
Vagus nerve stimulation;Intractable childhood epilepsy
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