Lithium-Pilocarpine으로 유발된 중첩경련 흰쥐 모델에서 Ketamine의 항경련 및 신경 보호 효과
Antiepileptic and Neuroprotective Effect of Ketamine in Lithium-Pilocarpine Induced Status Epilepticus Rat Model
고석범, 박성경, 손영민, 김영인,
소속 상세정보
고석범 ( Ko Seok-Bum )
가톨릭대학교 의과대학 신경과학교실
박성경 ( Park Soung-Kyeong )
가톨릭대학교 의과대학 신경과학교실
손영민 ( Shon Young-Min )
가톨릭대학교 의과대학 신경과학교실
김영인 ( Kim Yeong-In )
가톨릭대학교 의과대학 신경과학교실
KMID : 0877220040080010026
Abstract
Purpose：To examine the putative seizure-protective properties of ketamine in lithium-pilocarpine induced status epilepticus (LPSE).
Methods：Lithium chloride followed 24 h later by pilocarpine was administered for seizure induction. Ketamine (40 mg/kg) or phenytoin (50 mg/kg) was injected intraperitoneally 10 min or 60 min after the onset of continuous ictal discharge. Then the seizure behavior and EEG were observed and histological changes were compared through Nissl stain at 72 hours.
Results：The antiepileptic effect of ketamine, injected during the early stages of LPSE (10 min after the onset of continuous ictal discharge), was comparable to that of phenytoin. Ketamine was more effective than phenytoin in decreasing spike frequency, when administered on the plateau of LPSE (injection 60 min after onset of continuous ictal discharge electrographically). Anticonvulsant action of ketamine was confirmed by a less neuronal injury in hippocampus compared with control rats injected with phenytoin.
Conclusions：In prolonged status epilepticus rat model, ketamine was effective as an antiepileptic, but phenytoin was not. Ketamine was also neuroprotective on the neuronal injury in the hippocampus. These results suggest that ketamine might be useful as an antiepileptic drug when standard antiepileptic drugs fail in the treatment of the refractory cases of status epilepticus.
키워드
Lithium-pilocarpine induced status epilepticus;Ketamine;NMDA receptor;GABAA receptor;Neuroprotective effect
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