주의력결핍-과잉행동장애를 동반한 소아 간질환자에서 Methylphenidate의 효과 및 안전성
Efficacy and Safety of Methylphenidate in Children with Epileps and Attention Deficit Hyperactivity Disorder
박중채, 임경화, 강훈철, 김흥동,
소속 상세정보
박중채 ( Park Jung-Chae )
소화아동병원 소아과
임경화 ( )
연세대학교 의과대학 소아과학교실
강훈철 ( Kang Hoon-Chul )
인제대학교 의과대학 상계백병원 소아과
김흥동 ( Kim Heung-Dong )
연세대학교 의과대학 소아과학교실
KMID : 0877220050090020153
Abstract
Purpose: Twenty percent or more of children with epilepsy may have attention deficit hyperactivity disorder (ADHD). The treatment of ADHD with epilepsy has been an important clinical issue. The aim of this study is to investigate the efficacy and safety of methylphenidate in children with epilepsy and ADHD.
Methods: The subjects were 38 children with ADHD accompanied by epilepsy diagnosed at Department of Pediatrics and Epilepsy Center, Sanggye Paik Hospital. They were examined with IQ testing and Conners scales at baseline before using methylphenidate, and follow-up study was repeated 1 year after methylphenidate. Efficacy was determined by Conners scales and IQ score results. Safety was determined by measuring changes in seizure frequency, and electroencephalographic findings.
Results: According to their parents and teachers’ reports, methylphenidate improved ADHD symptoms in 24 children (63.2%). Three of them (7.9%) showed significant improvement in IQ scores and 7 children (18.4%) revealed significant improvement in cognitive function with rising IQ scores between 10 and 15 points. There were no worsening in seizure frequency, and electroencephalographic findings after methylphenidate.
Conclusion: Methylphenidate is effective and safe treatment in children with epilepsy and ADHD, showing significant benefit on children’s behavior and academic improvement in many cases.
키워드
Childhood epilepsy;ADHD;Methylphenidate
원문 및 링크아웃 정보
등재저널 정보