폐섬유화를 보인 paraquat 중독의 치료 2예
Two cases of successful management of paraquat poisoning with pulmonary fibrosis
소속 상세정보
주민하/Min Ha Joo
구자룡/윤종우/이정열/노희종/전만조/김진철/김근호/전노원/김형직/채동완/노정우/Ja Ryong Koo/Jong Woo Yoon/Jeong Yeol Lee/Hee Jong Noh/Man Jo Jeon/Jin Cheol Kim/Gheun Ho Kim/Rho Won Chun/Hyung Jik Kim/Dong Wan Chae/Jung Woo Noh
KMID : 0882420010600050490
Abstract
Paraquat는 중독으로 폐손상이 초래된 경우 거의 대부분이 사망하는 것으로 알려져 있어 치료를 포기하는 경우가 많다. 그러나 저자들은 paraquat 음독 후 저산소증과 폐섬유화가 동반되었으나 초기부터 적극적인 치료를 시행하여 생존한 예를 경험하였고 문헌
고찰을
통해
이를 확인하였기에 보고하는 바이다.
Paraquat, a very potent herbicide, has produced many fatalities through indiscriminate usage and suicides. It is known that with ingestion of more than one mouthful of 20% paraquat, death usually occurs by pulmonary fibrosis.
We experienced two cases of successful outcome in patients with paraquat poisoning complicated with pulmonary fibrosis through active, intensive treatment from the early phase after ingestion. They swallowed one to two mouthfuls of the 20%
commercial
paraquat, and received hemoperfusion within 2-3 hours after ingestion. Then, combination therapy with steroid, vitamin C, D-penicillamine, allopurinol, colchicine was administered from the early phase. They showed moderate to severe hypoxemia and
pulmonary fibrosis on chest HRCT during hospital course, but recovered from hypoxemia and remained very well on follow up over 3 months and 12 months after ingestion, respectively. We report these cases with literature review on treatment and
prognosis
of paraquat poisoning.
키워드
Paraquat; Pulmonary fibrosis;
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