편평상피세포암과 동반된 소세포폐암에서 발생한 항이뇨호르몬 분비이상 증후군 (SIADH) 1예
A case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) is small cell cancer of lung combined with squamous cell cancer of lung
소속 상세정보
윤병구/Byung Gu Yoon
장재식/유석동/구정태/이영실/이창화/천우정/정희철/강혁주/서영범/이창우/이영현/장태정/Jae Sik Jang/Seok Dong Yoo/Jung Tae Gu/Young Sil Lee/Chang Hwa Lee/Woo Jung Chun/Hee Churl Jung/Hyeock Joo Kang/Young Beom Suh/Chang Woo Lee/Young Hyun Lee/Tae Jung Jang
KMID : 0882420010610050562
Abstract
소세포혜암에서 흔히 발생하는 종양수반 증후군인 SIADH는 비소세포폐암에서도 드물게 발생하지만, 비소세포암과 동반된 소세포폐암에서 발생한 SIADH를 보고한 문헌은 아직 없다. 저자들은 기침과 현기증을 주소로 내원한 73세 여자 환자에서 보인 SIADH의 원인을
찾던
중 단순한 소세포암이 아니라 소세포폐암과 편평상피세포암이 동반된 폐암 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the term applied to arginine vasopressin (AVP) excess associated with hyponatremia without edema in the absence of physiologic of phamacologic stimuli to AVP secretion. SIADH is
associated with various conditions such as malignant tumors, infection, central nervous system disorders, and different phamacological agents. The patient was 73-year-old female. She was admitted to the hospital because of persistent cough,
dizziness,
general weakness and confusion. On admission, her serum osmolality was 253 mOsm/㎏, urine osmolality was 416 mOm/㎏, and urine Na concentration was 159 mEq/L. Her Chest X-ray and CT scan of lung showed about 4×3.5 ㎝ sized mass at posterior
basal
segment of left lower lobe of the lung, and CT-guided percutaneous needle aspiration revealed small round cell with clusters of malignant squamous cells. She was treated by salt restriction, hypertonic saline infusion and demeclocycline. We
planned
chemotherapy for advanced combined lung cancer, but she was discharged because of poor general condition and associated pneumonia without cancer chemotherapy. We report a rare case of SIADH in small cell cancer of lung combined with squamons cell
cancer
of lung.
키워드
Inappropriate ADH syndrome; Small cell Carcinoma; Squamous cell Carcinoma;
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