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Tacrolimus-Induced Fever in a Patient Undergoing Kidney Transplantation
김성규, 이인희, 강건우,
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김성규 ( Kim Seong-Gyu )
대구가톨릭대학교 의과대학 내과학교실
이인희 ( Lee In-Hee )
대구가톨릭대학교 의과대학 내과학교실
강건우 ( Kang Gun-Woo )
대구가톨릭대학교 의과대학 내과학교실
Abstract
Tacrolimus is widely used with other immunosuppressive agents to prevent rejection of a kidney transplant (KT). However, tacrolimus-induced fever is very rarely diagnosed. We report a case of tacrolimus-induced fever after KT. A 53-year-old female was diagnosed with cytomegalovirus (CMV) viremia. She had received a KT 2 months previously. Ganciclovir was started immediately at that time. A fever developed on day 12 of admission. Because of dysuria and a residual urine sensation with pyuria, we started intravenous antibiotics to treat urinary tract infection. Although other infectious reasons were ruled out and CMV viremia and the urinary tract infection improved, the fever spike did not improve. Thus, we suspected drug-induced fever. First, the ganciclovir and antibiotics were discontinued. However, the fever continued. To exclude tacrolimus-induced fever, tacrolimus was discontinued and cyclosporine was used with other immunosuppressive agents. Tacrolimus was discontinued after 1 day and the fever was no longer confirmed.
키워드
Tacrolimus; Fever; Kidney transplantation
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