비만의 소화관 생리변화
Changes in Gastrointestinal Physiology in Obese Patients
윤소희, 박종규, 신정은,
소속 상세정보
윤소희 ( Yun So-Hee )
예수병원 소화기내과
박종규 ( Park Jong-Kyu )
울산대학교 의과대학 강릉아산병원 내과학교실 소화기내과
신정은 ( Shin Jeong-Eun )
단국대학교 의과대학 내과학교실
Abstract
Obesity is a prevalent disease with significant morbidity and mortality. It is a state of chronic low-grade inflammation due to excess body fat. Weight homeostasis is maintained through changes in various gastrointestinal hormones caused by dietary intake. However, being overweight or obese breaks the balance of these appetite-related gastrointestinal hormones and creates resistance to the actions of these hormones. The sensitivity of vagal afferent neurons to peripheral signals becomes blunted. Cytokines produced by excessive fat tissue damage our normal immune system, making us vulnerable to infection. In addition, various changes in gastrointestinal motility occur. Therefore, this review focuses on the various changes in gastrointestinal hormones, the immune state, the vagus nerve, and gastrointestinal movement in obese patients.
키워드
비만; 호르몬; 면역; 미주신경; 위장관 운동
Obesity; Hormones; Immunity; Vagus nerve; Gastrointestinal motility
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