비소세포폐암의 표적 치료
Targeted Therapy for Non-Small Cell Lung Cancer
김정선, 강은주,
소속 상세정보
김정선 ( Kim Jung-Sun )
고려대학교 의과대학 내과학교실
강은주 ( Kang Eun-Joo )
고려대학교 의과대학 내과학교실
Abstract
Treatment of progressive non-small cell lung cancer (NSCLC) has advanced remarkably, due in part to the development of targeted therapies. Several gene alterations, including EGFR, ALK, ROS1, and BRAF, play important roles in carcinogenesis. Therefore, many targeted agents focusing these gene alterations have been developed and proving their therapeutic efficacies in many clinical trials. Now we should test these gene mutations and should apply treatments individually and properly to ensure the maximal survival benefit of each patient. In this review, we summarize the target genes and respective therapeutic agents in NSCLC.
키워드
Non-small cell lung cancer; Molecular targeted therapy; Biomarkers
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