급성 심근경색증 환자에서 관상동맥 중재술 후 허혈성 심근병증 예측인자
Predictors of Ischemic Cardiomyopathy in Patients with Acute Myocardial Infarction who Underwent Percutaneous Coronary Intervention
김혜숙, 정명호, 윤현주, 김용철, 손석준, 김민철, 심두선, 홍영준, 김주한, 안영근, 조재영, 김계훈, 박종춘,
소속 상세정보
김혜숙 ( Kim Hye-Sook )
Chonnam National University Hospital The Heart Center
정명호 ( Jeong Myung-Ho )
Chonnam National University Hospital The Heart Center
윤현주 ( Yoon Hyun-Ju )
Chonnam National University Hospital The Heart Center
김용철 ( Kim Yong-Cheol )
Chonnam National University Hospital The Heart Center
손석준 ( Sohn Seok-Joon )
Chonnam National University Medical School Department of Preventive Medicine
김민철 ( Kim Min-Chul )
Chonnam National University Hospital The Heart Center
심두선 ( Sim Doo-Sun )
Chonnam National University Hospital The Heart Center
홍영준 ( Hong Young-Joon )
Chonnam National University Hospital The Heart Center
김주한 ( Kim Ju-Han )
Chonnam National University Hospital The Heart Center
안영근 ( Ahn Young-Keun )
Chonnam National University Hospital The Heart Center
조재영 ( Cho Jae-Young )
Chonnam National University Hospital The Heart Center
김계훈 ( Kim Kye-Hun )
Chonnam National University Hospital The Heart Center
박종춘 ( Park Jong-Chun )
Chonnam National University Hospital The Heart Center
Abstract
Background/Aims: Many patients with acute myocardial infarction (AMI) suffer from heart failure due to progressive ischemic left ventricular (LV) remodeling. This study investigated the predictors of ischemic cardiomyopathy (ICMP) in patients with AMI who underwent successful percutaneous intervention.
Methods: A total of 547 patients with AMI were divided into two groups: ICMP (n = 66, 67.1 ± 11.9 years, 78.8% males) and non-ICMP (n = 481, 62.5 ± 12.2 years, 70.1% males).
Results: On echocardiography, the LVEF was significantly decreased (41.7 ± 10.5 vs. 55.4 ± 10.3%, p < 0.001) but the LV end-diastolic (54.1 ± 7.2 vs. 49.3 ± 5.3 mm, p < 0.001) and systolic (42.1 ± 8.0 vs. 33.5 ± 6.0 mm, p < 0.001) dimensions significantly increased in the ICMP group compared with the non-ICMP group. According to multivariate logistic regression analysis, LVEF < 50% (odds ratio [OR] 8.722, 95% confidence interval [CI] 2.986?25.478, p < 0.001), LV end-diastolic dimension > 55 mm (OR 4.511, 95% CI 1.561?13.038, p = 0.005), and ratio of early mitral inflow velocity to mitral annular early diastolic velocity (E/e’) ≥ 15 (OR 3.270, 95% CI 1.168?9.155, p = 0.024) were independent predictors of ICMP development.
Conclusions: The present study demonstrates that a larger LV size, lower LV function, and increased E/e’ (≥ 15) were independent predictors of ICMP. Therefore, the development of ICMP should be carefully monitored in AMI patients with these features.
키워드
Cardiomyopathies; Myocardial infarction; Prognosis
원문 및 링크아웃 정보
등재저널 정보