급성 뇌경색을 동반한 당뇨 환자에게 Dapagliflozin 투여 후 발생한 급성 신손상 1예
Acute Kidney Injury after Administering Dapagliflozin to a Diabetic Patient with Acute Cerebral Infarction
박창현, 이은경, 김소미, 조종태, 이도현, 이지은, 전지현,
소속 상세정보
박창현 ( Park Chang-Hyun )
Dankook University College of Medicine Dankook University Hospital Department of Internal Medicine
이은경 ( Lee Eun-Kyoung )
Dankook University College of Medicine Dankook University Hospital Department of Internal Medicine
김소미 ( Kim So-Mi )
Dankook University College of Medicine Dankook University Hospital Department of Internal Medicine
조종태 ( Cho Jong-Tae )
Dankook University College of Medicine Dankook University Hospital Department of Internal Medicine
이도현 ( Lee Do-Hyun )
Baek-jae General Hospital Department of Internal Medicine
이지은 ( Lee Ji-Eun )
Daejeon Chamsarang Convalescent Hospital Department of Internal Medicine
전지현 ( Jeon Ji-Hyun )
Dankook University College of Medicine Dankook University Hospital Department of Internal Medicine
Abstract
Dapagliflozin is a recently developed oral anti-diabetic drug and SGLT2 inhibitor with well-known cardioprotective and renoprotective effects. Although a reduction of the glomerular filtration rate is induced by volume depletion and tubule-glomerular feedback during the early period after administering a SGLT2 inhibitor, the renal prognosis improves more with a decrease of proteinuria. However, the risk of acute kidney injury increases in heart failure and hypovolemia patients, and in those taking certain drugs, such as non-steroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers, or diuretics. We report acute kidney injury after dapagliflozin administration in a diabetic patient with acute cerebral infarction accompanied by right hemiplegia, motor aphasia, and dysphagia.
키워드
다파글리플로진; 급성 신손상; 뇌경색
Dapagliflozin; Acute kidney injury; Cerebral infarction
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