Impact of Multiple Prostate Biopsies: Risk of Perioperative Complications and Biochemical Recurrence After Radical Prostatectomy
박경민, 정재욱, 강준구, 신택준, 권세윤, 장현찬, 하윤석, 최석환, 정원호, 이준녕, 김병훈, 김범수, 김현태, 김재수, 김태환, 유은상, 이경섭, 김천일, 정성광, 권태균,
소속 상세정보
박경민 ( Park Kyong-Min )
Kyungpook National University School of Medicine Department of Urology
정재욱 ( Chung Jae-Wook )
Kyungpook National University School of Medicine Department of Urology
강준구 ( Kang Jun-Koo )
Kyungpook National University School of Medicine Department of Urology
신택준 ( Shin Teak-Jun )
Keimyung University School of Medicine Department of Urology
권세윤 ( Kwon Se-Yun )
Dongguk University College of Medicine Department of Urology
장현찬 ( Jang Hyun-Chan )
Daegu Fatima Hospital Department of Urology
하윤석 ( Ha Yun-Sok )
Kyungpook National University School of Medicine Department of Urology
최석환 ( Choi Seock-Hwan )
Kyungpook National University School of Medicine Department of Urology
정원호 ( Jung Won-Ho )
Keimyung University School of Medicine Department of Urology
이준녕 ( Lee Jun-Nyung )
Kyungpook National University School of Medicine Department of Urology
김병훈 ( Kim Byung-Hoon )
Keimyung University School of Medicine Department of Urology
김범수 ( Kim Bum-Soo )
Kyungpook National University School of Medicine Department of Urology
김현태 ( Kim Hyun-Tae )
Kyungpook National University School of Medicine Department of Urology
김재수 ( Kim Jae-Soo )
Daegu Fatima Hospital Department of Urology
김태환 ( Kim Tae-Hwan )
Kyungpook National University School of Medicine Department of Urology
유은상 ( Yoo Eun-Sang )
Kyungpook National University School of Medicine Department of Urology
이경섭 ( Lee Kyung-Seop )
Dongguk University College of Medicine Department of Urology
김천일 ( Kim Chun-Il )
Keimyung University School of Medicine Department of Urology
정성광 ( Chung Sung-Kwang )
Kyungpook National University School of Medicine Department of Urology
권태균 ( Kwon Tae-Gyun )
Kyungpook National University School of Medicine Department of Urology
Abstract
Purpose: The aim of this study was to analyze the perioperative complications and oncological outcomes of radical prostatectomy (RP) in patients who underwent multiple prostate biopsies.
Materials and Methods: A total of 1,112 patients who underwent RP between January 2009 and April 2016 at 4 different centers were included in this study. We divided these patients into 2 groups: patients who underwent only 1st biopsy, and those who underwent 2nd or more repeated biopsies. The association between the number of prior biopsies and perioperative complications and biochemical recurrence (BCR) was analyzed.
Results: Of 1,112 patients, 1,046 patients (94.1%) underwent only 1st biopsy, and 66 (5.9%) underwent 2nd or more repeated biopsies. There were no significant differences in preoperative prostate-specific antigen levels, operation times, blood loss volumes, or hospital stay durations (all p＞0.05). Patients who underwent multiple prostate biopsies presented with a localized tumor significantly more often (p＜0.05). The Gleason score and rate of positive surgical margins were significantly lower in patients with multiple biopsies (all p＜0.05). The Cox proportional hazards model analysis indicated that there was no association between the number of prior prostate biopsies and BCR (p＞0.05). Kaplan-Meier curve analysis indicated that BCR-free survival rates between the 2 groups were similar (p＞0.05).
Conclusions: Multiple prostate biopsies are not associated with an increased risk of perioperative complications, adverse pathological outcomes, or higher rates of BCR in patients who have undergone RP.
키워드
Prostate cancer;Radical prostatectomy;Multiple prostate biopsy;Perioperative complication; Biochemical recurrence
원문 및 링크아웃 정보
등재저널 정보