Serum Testosterone Level Can Be Predictive Factor for Upstaging in Clinically Localized Prostate Cancer
권순오, 변경현, 정재욱, 하윤석, 최석환, 김범수, 김현태, 김태환, 유은상, 윤길석, 이준녕, 권태균,
소속 상세정보
권순오 ( Kwon Soon-Oh )
Kyungpook National University School of Medicine Department of Urology
변경현 ( Byeon Kyeong-Hyeon )
Kyungpook National University School of Medicine Department of Urology
정재욱 ( Chung Jae-Wook )
Kyungpook National University School of Medicine Department of Urology
하윤석 ( Ha Yun-Sok )
Kyungpook National University School of Medicine Department of Urology
최석환 ( Choi Seock-Hwan )
Kyungpook National University School of Medicine Department of Urology
김범수 ( Kim Bum-Soo )
Kyungpook National University School of Medicine Department of Urology
김현태 ( Kim Hyun-Tae )
Kyungpook National University School of Medicine Department of Urology
김태환 ( Kim Tae-Hwan )
Kyungpook National University School of Medicine Department of Urology
유은상 ( Yoo Eun-Sang )
Kyungpook National University School of Medicine Department of Urology
윤길석 ( Yoon Ghil-Suk )
Kyungpook National University School of Medicine Department of Pathology
이준녕 ( Lee Jun-Nyung )
Kyungpook National University School of Medicine Department of Urology
권태균 ( Kwon Tae-Gyun )
Kyungpook National University School of Medicine Department of Urology
Abstract
Purpose: To determine an appropriate surgical technique, it is important to predict pathological results for patients with clinically localized prostate cancer (PCa) eligible for nerve-sparing radical prostatectomy (NSRP). Several studies have highlighted that serum testosterone level was associated with aggressive features of PCa. Therefore, we analyzed factors, including serum testosterone, to predict upstaging and upgrading after surgery for patients with clinically localized PCa eligible for NSRP.
Materials and Methods: We retrospectively evaluated patients who underwent radical prostatectomy (RP) between January 2015 and May 2018 at our institution. Patients with Gleason grade group 1 or 2 on biopsy, prostate-specific antigen<10, and ≤clinical/radiologic stage T2 were included in this study. Upstaging and upgrading were defined as pathological stage≥T3a and Gleason grade group≥3, respectively. We evaluated the patients’ demographics and outcomes according to upstaging and upgrading after surgery. Predictive factors for upstaging and upgrading were analyzed using a multivariate logistic regression model.
Results: Of 108 patients included in the study, upstaging and upgrading after surgery were observed in 24 (22.2%) and 36 (33.3%), respectively. Low serum testosterone level, small prostate size, and positive core number≥3 on biopsy were identified as predictive factors for upstaging in multivariate analysis. Although serum testosterone was associated with upgrading in univariate analysis, only clinical/radiologic stage and biopsy Gleason grade group were observed as predictive factors for upgrading in multivariate analysis.
Conclusions: Serum testosterone level was identified as a predictive factor for upstaging after RP for clinically localized PCa eligible for NSRP.
키워드
Pathology; Prostate cancer; Prostatectomy; Testosterone; Treatment outcome
원문 및 링크아웃 정보
등재저널 정보