Radiographic Features in a Patient Diagnosed with Neurosyphilis
박윤아, 안정우, 전석희, 정은주, 김응규, 박중현, 이석모,
소속 상세정보
박윤아 ( Park Yoon-Ah )
Kosin University College of Medicine Department of Neurology
안정우 ( Ann Jung-Woo )
Inje University College of Medicine Busan Paik Hospital Department of Neurology
전석희 ( Jeon Seok-Hwi )
Inje University College of Medicine Busan Paik Hospital Department of Neurology
정은주 ( Chung Eun-Joo )
Inje University College of Medicine Busan Paik Hospital Department of Neurology
김응규 ( Kim Eung-Gyu )
Inje University Dementia and Neurodegenerative Disease Research Center
박중현 ( Park Joong-Hyun )
Inje University College of Medicine Sanggye Paik Hospital Department of Neurology
이석모 ( Lee Seok-Mo )
Inje University College of Medicine Busan Paik Hospital Department of Nuclear Medicine
Abstract
The clinical features and brain magnetic resonance image (B-MRI) findings in neurosyphilis (NS) are highly varied. Cortical atrophy, especially involving the medial temporal lobes (MTL), is a remarkable radiographic feature, reported in B-MRI scans, in cases of NS presenting with severe cognitive impairments. The observed MTL atrophy is similar to the atrophy seen in neurodegenerative disorders such as Alzheimer’s disease (AD) or frontotemporal dementia (FTD). A fluorodeoxy- glucose-positron emission tomography (FDG-PET), used for the diagnosis of AD, commonly reveals global cortical hypometabolism, sparing basal ganglia and thalamus, in NS. We report a case of NS, with complex symptoms and bilateral MTL atrophy. FDG-PET imaging showed bilateral thalamic and right visual cortical glucose reduction, as well as diffuse cortical hypometabolism. This type of FDG-PET pattern is a new finding in the field of NS.
키워드
Neurosyphilis; Magnetic resonance imaging; Mesial temporal lobes; Fluorodeoxyglucose F18 positron-emission tomography
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