The Relationship between Changes in Systemic Blood Viscosity and Transcranial Doppler Pulsatility in Lacunar Stroke
김태민, 오진영, 한지은, 박중현, 백종삼, 김정연, 박재현, 한상원, 김응규,
소속 상세정보
김태민 ( Kim Tae-Min )
Inje University College of Medicine Sanggye Paik Hospital Department of Neurology
오진영 ( Oh Jin-Young )
Inje University College of Medicine Sanggye Paik Hospital Department of Neurology
한지은 ( Han Ji-Eun )
Inje University College of Medicine Sanggye Paik Hospital Department of Neurology
박중현 ( Park Joong-Hyun )
Inje University College of Medicine Sanggye Paik Hospital Department of Neurology
백종삼 ( Baik Jong-Sam )
Inje University College of Medicine Sanggye Paik Hospital Department of Neurology
김정연 ( Kim Jeong-Yeon )
Inje University College of Medicine Sanggye Paik Hospital Department of Neurology
박재현 ( Park Jae-Hyeon )
Inje University College of Medicine Sanggye Paik Hospital Department of Neurology
한상원 ( Han Sang-Won )
Inje University College of Medicine Sanggye Paik Hospital Department of Neurology
김응규 ( Kim Eung-Gyu )
Inje University College of Medicine Busan Paik Hospital Department of Neurology
Abstract
Background: We hypothesized that changes in blood viscosity (BV) would influence cerebral vessel viscosity, which is related to the transcranial Doppler (TCD) pulsatility index (PI). Using serial BV and TCD examinations, we sought to evaluate the relationship between changes in BV and TCD PI in lacunar stroke patients.
Methods: Patients (aged ≥50 years) who developed lacunar stroke within 7 days of symptom onset were enrolled. Laboratory tests and TCD examinations were conducted at admission and 180 (±30) days after the onset of stroke. Patients were categorized into the decreased BV and increased BV groups. Decreased BV suggested that the BV value in the baseline study minus the 180-day study was positive, and vice-versa.
Results: A total of 128 patients who had experienced classic lacunar syndromes were enrolled and 67 (52%) were included in the final analysis. At the end of the 180-day study, changes in systolic BV (SBV) were not associated with PI changes. Regarding diastolic BV (DBV), hematocrit (Hct) adjusted partial correlation analysis showed no significant relationship between changes in DBV and PI (r=0.25, p=0.068). The correlation analysis showed that changes in hemoglobin and Hct were positively associated with SBV and DBV changes (r>0.488, p<0.0001 and r>0.461, p<0.0001), confirming that Hct was the major determinant factor of BV.
Conclusion: This study did not show a relationship between changes in BV and cerebral arterial pulsatility in patients with lacunar stroke. The changes in BV were positively associated with changes in Hct.
키워드
Blood viscosity; Stroke; Ultrasonography
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