응급실에 내원한 불완전 가와사키병 환아에서 심혈관 합병증을 예측하기 위한 인자로서 Pro-BNP의 유용성
Pro-brain natriuretic peptide as predictive factor for cardiovascular abnormalities in children with incomplete Kawasaki disease in emergency department
조성필, 강민경, 문형준, 이정원, 김종원,
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조성필 ( Jo Sung-Pill )
순천향대학교 의과대학 응급의학교실
강민경 ( Kang Min-Kyoung )
순천향대학교 의과대학 응급의학교실
문형준 ( Moon Hyung-Jun )
순천향대학교 의과대학 응급의학교실
이정원 ( Lee Jung-Weon )
순천향대학교 의과대학 응급의학교실
김종원 ( Kim Jong-Won )
순천향대학교 의과대학 응급의학교실
KMID : 1037620150020020075
Abstract
Purpose: The prevalence of incomplete Kawasaki disease (KD) is progressively increasing. The purpose of our study is to investigate the usefulness of pro-brain natriuretic peptide (pro-BNP) assay as a predictive biochemical marker of cardiovascular abnormality in children with incomplete KD.
Methods: We retrospectively reviewed medical records of patients under 15 years of age with incomplete KD in the pediatric emergency department (PED) of Soonchunhyang University Cheonan Hospital from January 2010 to December 2014. Incomplete KD was diagnosed in 132 children, including 67 boys and 65 girls, aged 2 to 83 months (mean, 24.9 months). We assessed the risk of cardiovascular abnormality in relation to age, gender, duration of fever, symptoms, and laboratory data.
Results: The distribution of epidemiologic characters, laboratory findings except platelet counts, and pro-BNP in the patient group without cardiovascular abnormality absent group did not significantly differ from those of the patient group with cardiovascular abnormality group. However, in the latter group with cardiovascular abnormality, serum platelet counts were significantly lower and concentration of pro-BNP levels were significantly higher.
Conclusion: Pro-BNP might be a useful and important value for predicting cardiovascular abnormality in incomplete KD at PED. Therefore, incomplete KD patients with high concentraton of pro-BNP need further evaluation for cardiovascular abnormality
키워드
Kawasaki Disease; Pro-brain natriuretic peptide; Cardiovascular Abnormalities; Complications; Risk Factors
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