약물의 형태학적 차이에 따른 유소아 중독의 특징
Characteristics of poisoning in younger children according to different forms of the drugs
장민, 고유라, 양희원, 이지숙,
소속 상세정보
장민 ( Jang Min )
아주대학교 의과대학 응급의학과교실
고유라 ( Ko Yu-Ra )
아주대학교 의과대학 응급의학과교실
양희원 ( Yang Hee-Won )
아주대학교 의과대학 응급의학과교실
이지숙 ( Lee Ji-Sook )
아주대학교 의과대학 응급의학과교실
Abstract
Purpose: This study aimed to investigate the characteristics of poisoning drug ingested by younger children, and to compare the clinical outcome by drug forms.
Methods: This was a retrospective analysis based on medical records from the Emergency Department based Injury In-depth Surveillance (EDIIS) registry in Korea from January to December 2015. Patients aged 7 years or younger visiting the emergency department (ED) with drug poisoning were included. We classified the forms of drugs as tablets or syrup, and analyzed the characteristics by size, color, and shape. In addition, clinical outcomes and ED length of stay were compared according to the drug forms.
Results: A total of 308 cases were collected, and 202 patients finally were analyzed. Tablets and capsules (TACs) were more common than syrup (67.3% vs. 32.7%). Regarding clinical outcomes, patients who took TACs had higher admission rate (18.4% vs. 7.6%, P = 0.040) without a significant difference in ED length of stay compared to those who took syrups. While commonly ingested drugs in TACs were hormones, sedative and analgesics, frequent drugs in syrup were antihistamines and cold drugs. In 136 case of TACs, median long and short axes were 0.85 cm (interquartile range [IQR], 0.7-1.1 cm) and 0.72 cm (IQR, 0.59-0.82 cm), respectively. Chromatic TACs were 80 cases (52.8%) and more common than achromatic TACs. Round shapes were preferred than angular ones (96.3% vs. 3.7%).
Conclusion: In younger children poisonings, the TACs showed higher incidence and admission rate compared to syrups. Especially, chromatic TACs and round shapes were preferred. Therefore, drugs with these characteristics need to be stored more carefully.
키워드
Child; Dosage forms; Drug Compounding; Poisoning; Syrup; Tablets
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