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A child with Kawasaki disease and genetic warfarin sensitivity from CYP2C9 and VKORC1 gene variants
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ÀÌ¸í¼· ( Lee Myeong-Seob )
Yonsei University College of Medicine Department of Pediatircs
Àº¿µ¹Î ( Eun Young-Min )
Yonsei University College of Medicine Department of Pediatrics
Abstract
Kawasaki disease (KD) is a common febrile disease in East Asia. Because KD with coronary artery aneurysm (CAA) may predispose to thrombosis, children with KD-associated CAA may need anticoagulation in addition to aspirin. In this report, we describe a 6-year-old girl with KD and CAA who was found to have unexpected warfarin-induced coagulopathy caused by CYP2C9 and VKORC1 genotype variants, which affect warfarin metabolism.
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Anticoagulants; Coronary Aneurysm; Cytochrome P-450 Enzyme System; Mucocutaneous Lymph Node Syndrome; Warfarin
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