Macrolide 불응성 마이코플라즈마 폐렴과 적혈구포식림프조직구증: 증례보고와 문헌고찰
Macrolide-refractory Mycoplasma pneumoniae pneumonia and hemophagocytic lymphohistiocytosis: case report and literature review
마성연, 김단비, 이주영, 조경순, 서진순, 이수영,
소속 상세정보
마성연 ( Ma Sung-Yun )
Catholic University College of Medicine Department of Pediatrics
김단비 ( Kim Dan-Bi )
Catholic University College of Medicine Department of Pediatrics
이주영 ( Lee Ju-Young )
Catholic University College of Medicine Department of Pediatrics
조경순 ( Cho Kyoung-Soon )
Catholic University College of Medicine Department of Pediatrics
서진순 ( Suh Jin-Soon )
Catholic University College of Medicine Department of Pediatrics
이수영 ( Lee Soo-Young )
Catholic University College of Medicine Department of Pediatrics
Abstract
Mycoplasma pneumoniae causes various extra-pulmonary complications. As a rare but fatal hematological complication, hemophagocytic lymphohistiocytosis (HLH) can be observed in children with M. pneumoniae infection. We report a case of a 6-year-old girl with HLH who was initially presumed to have macrolide-refractory M. pneumoniae pneumonia. Despite the combination treatment of antimicrobial and anti-inflammatory agents, she showed persistent fever, hepatosplenomegaly, and thrombocytopenia. Secondary HLH associated with M. pneumoniae should be considered if unexplained clinical deterioration is noted in children with macrolide-refractory M. pneumoniae pneumonia.
키워드
Child; Lymphohistiocytosis, Hemophagocytic; Macrolides; Mycoplasma pneumoniae; Treatment Failure
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