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4D Flow MRI¸¦ È°¿ëÇÑ Ç÷·ù¿ªÇÐÀû ÀÎÀÚÀÇ ÃøÁ¤¹ý Quantification of Hemodynamic Parameters Using Four-Dimensional Flow MRI

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Abstract

ÀÚ±â°ø¸í¿µ»ó(ÀÌÇÏ MRI) ±â¼úÀº ºñħ½ÀÀû ¹× ºñÀÌ¿ÂÈ­ ¹æ¹ýÀ¸·Î ½ÉÇ÷°ü ½Ã½ºÅÛÀÇ ÇغÎÇÐÀû Á¤º¸¸¦ Á¦°øÇÑ´Ù. MRI´Â Å»ýÀûÀ¸·Î Ç÷·ùÀÇ À¯µ¿¿¡ ¹Î°¨¼ºÀ» °¡Áö±â ¶§¹®¿¡, À̸¦ ±â¹ÝÀ¸·Î MRI´Â ÇÑ ¹øÀÇ ÃøÁ¤À¸·Î ÇغÎÇÐ µ¥ÀÌÅͻӸ¸ ¾Æ´Ï¶ó ȯÀÚÀÇ Ç÷·ùÀÇ À¯Ã¼¿ªÇÐÀûÀΠƯ¡À» µ¿½Ã¿¡ ÃëµæÇÒ ¼ö ÀÖ´Ù. ƯÈ÷, ½Ã°£ºÐÇØ´ÉÀ» °¡Áö¸ç 3Â÷¿ø Ç÷°ü¿¡¼­ ÀϾ´Â Ç÷·ù¸¦ ÃøÁ¤ °¡´ÉÇÑ 4D Flow MRI´Â ÃÖ±Ù ¸î ³â µ¿¾È »ó´çÇÑ ¹ßÀüÀ» ÀÌ·ç¾ú´Ù. À̹ø Á¾¼³¿¡¼­´Â 4D Flow MRIÀÇ ¿ø¸®¿Í ÃøÁ¤ ¹æ¹ýµéÀ» ¼Ò°³ÇÏ°íÀÚ ÇÑ´Ù. ƯÈ÷ º®¸éÀü´ÜÀÀ·Â(wall shear stress), ³­·ù¿îµ¿¿¡³ÊÁö(turbulent kinetic energy) ¹× »ó´ë ¾Ð·Â(relative pressure)À» Æ÷ÇÔÇÑ ÀÓ»óÀûÀ¸·Î È°¿ëÀÌ °¡´ÉÇÑ ´Ù¾çÇÑ À¯Ã¼¿ªÇÐÀû ¹ÙÀÌ¿À ¸¶Ä¿ÀÇ ¿ø¸®¿Í ÃøÁ¤¹ýÀ» ¼Ò°³ÇÏ°íÀÚ ÇÑ´Ù. ¸¶Áö¸·À¸·Î, ´Ù¾çÇÑ ½ÉÀå Ç÷°ü°è¿¡¼­ 4D Flow MRI¸¦ È°¿ëÇÏ¿© ÀÓ»óÀûÀ¸·Î Àû¿ëÇÑ ¿¹¸¦ ¼Ò°³ÇÏ°íÀÚ ÇÑ´Ù.

MRI provides non-invasive and non-ionizing methods for the accurate anatomic depiction of the cardiovascular system. Based on the inherent flow sensitivity, MRI can be used to investigate hemodynamic features in patients with anatomical data within a single measurement. In particular, time-resolved and three-dimensional (3D) characterization of blood flow using 4D flow MRI has achieved considerable progress in recent years. The present article reviews the principle and procedures of 4D Flow MRI. Various fluid dynamic biomarkers for possible clinical usage are also described, including wall shear stress, turbulent kinetic energy, and relative pressure. Finally, this article provides an overview of the clinical applications of 4D Flow MRI in various cardiovascular regions.

Å°¿öµå

Magnetic Resonance Imaging; Heart; Blood; Hemodynamics

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