Prognostic Significance of the Imaging Parameters of Adipose Tissue and Bone Marrow on F-18 Fluorodeoxyglucose PET/CT in Patients with Malignant Melanoma
이주하, 이상미, 김정은,
소속 상세정보
이주하 ( Lee Ju-Ha )
Soonchunhyang University Cheonan Hospital Department of Radiology
이상미 ( Lee Sang-Mi )
Soonchunhyang University Cheonan Hospital Department of Nuclear Medicine
김정은 ( Kim Jung-Eun )
Soonchunhyang University Cheonan Hospital Department of Dermatology
Abstract
Purpose: Fluorodeoxyglucose (FDG) uptake of bone marrow (BM) and adipose tissue is known to reflect systemic inflammatory response to cancer cell. The objective of this study was to evaluate the prognostic value of F-18 FDG uptake of BM and determine characteristics of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) on PET/CT images in malignant melanoma.
Materials and Methods: We retrospectively reviewed 33 patients histopathologically diagnosed with malignant melanoma via FDG PET/CT staging. BM-to-liver uptake ratio (BLR), volume of VAT and SAT, CT Hounsfield unit (HU), and mean of standardized uptake value (SUVmean) of VAT and SAT on PET/CT were measured and prognostic values of these parameters for prediction of disease progression-free survival (DPFS) were evaluated.
Results: Patients with stage III?IV melanoma had higher CT HU and SUVmean for SAT and VAT but lower volume of VAT compared with patients at stage I?II (p < 0.05). Survival analysis, patients with high CT HU of VAT and SAT, high SUVmean of VAT and SAT, and high BLR showed worse DPFS (all p < 0.05), indicating significant association. However, volume of SAT or VAT failed to show significant association with DPFS (p > 0.05).
Conclusion: CT HU, SUVmean of SAT and VAT, and BLR provide prognostic information for DPFS in malignant melanoma.
키워드
Malignant Melanoma; Prognosis; Intra-Abdominal Fat; Positron-Emission Tomography; Inflammation
원문 및 링크아웃 정보
등재저널 정보