Bilateral Triple Negative Invasive Ductal Breast Carcinoma in a BRCA1 Mutation Carrier with Discrepant Pathologic Response to Neoadjuvant Chemotherapy
신기원, 박영미, 김태현, 이안복, 박하영, 윤혜경, 허영진, 백진욱, 이유진,
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신기원 ( Shin Gi-Won )
Inje University College of Medicine Busan Paik Hospital Department of Radiology
박영미 ( Park Young-Mi )
Inje University College of Medicine Busan Paik Hospital Department of Radiology
김태현 ( Kim Tae-Hyun )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
이안복 ( Lee An-Bok )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
박하영 ( Park Ha-Young )
Inje University College of Medicine Busan Paik Hospital Department of Pathology
윤혜경 ( Yoon Hye-Kyoung )
Inje University College of Medicine Busan Paik Hospital Department of Pathology
허영진 ( Heo Young-Jin )
Inje University College of Medicine Busan Paik Hospital Department of Radiology
백진욱 ( Baek Jin-Wook )
Inje University College of Medicine Busan Paik Hospital Department of Radiology
이유진 ( Lee Yoo-Jin )
Inje University College of Medicine Busan Paik Hospital Department of Radiology
Abstract
Herein, we report a case of synchronous bilateral triple negative invasive ductal breast carcinoma in a patient with discrepant pathologic response to neoadjuvant chemotherapy. Right and left breast cancer stages at the initial diagnosis were T1cN0M0 and T4dN3aM0, respectively. The patient was identified as a BRCA1 mutation carrier and treated with four cycles of adriamycin and cyclophosphamide, followed by four cycles of docetaxel. Bilateral breast cancer stages decreased with the first regimen. However, the bilateral breast cancers showed discrepant responses to chemotherapy with docetaxel. The right breast cancer showed a continuous tumor volume reduction while the left breast cancer showed marked progression. Finally, the tumor size was 0.3 cm and 12 cm in the right and left mastectomy specimens, respectively. As bilateral breast cancers of the same subtype may show discrepant responses to neoadjuvant chemotherapy, close monitoring and follow-up imaging are required to avoid delayed surgery.
키워드
Breast Neoplasm; Carcinoma; Neoadjuvant Therapy; Triple Negative Breast Neoplasm
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