Structural and Resting-State Brain Alterations in Trauma-Exposed Firefighters: Preliminary Results
박예원, 전선영, 노주환, 정석종, 한상훈, 이필휴, 김창수, 이승구,
소속 상세정보
박예원 ( Park Yae-Won )
Ewha Womans University School of Medicine Department of Radiology
전선영 ( Jun Suhn-Young )
Yonsei University College of Medicine Department of Psychology
노주환 ( Noh Ju-Whan )
Yonsei University College of Medicine Department of Preventive Medicine
정석종 ( Chung Seok-Jong )
Yonsei University College of Medicine Department of Neurology
한상훈 ( Han Sang-Hoon )
Yonsei University College of Medicine Department of Psychology
이필휴 ( Lee Phil-Hyu )
Yonsei University College of Medicine Department of Neurology
김창수 ( Kim Chang-Soo )
Yonsei University College of Medicine Department of Preventive Medicine
이승구 ( Lee Seung-Koo )
Yonsei University College of Medicine Department of Radiology
Abstract
Purpose: To analyze the altered brain regions and intrinsic brain activity patterns in trauma-exposed firefighters without posttraumatic stress disorder (PTSD).
Materials and Methods: Resting-state functional MRI (rsfMRI) was performed for all subjects. Thirty-one firefighters over 40 years of age without PTSD (31 men; mean age, 49.8 ± 4.7 years) were included. Twenty-six non-traumatized healthy controls (HCs) (26 men; mean age, 65.3 ± 7.84 years) were also included. Voxel-based morphometry was performed to investigate focal differences in the brain anatomy. Seed-based functional connectivity analysis was performed to investigate differences in spontaneous brain characteristics.
Results: The mean z-scores of the Seoul Verbal Learning Test for immediate and delayed recall, Controlled Oral Word Association Test (COWAT) score for animals, and COWAT phonemic fluency were significantly lower in the firefighter group than in the HCs, indicating decreased neurocognitive function. Compared to HCs, firefighters showed reduced gray matter volume in the left superior parietal gyrus and left inferior temporal gyrus. Further, in contrast to HCs, firefighters showed alterations in rsfMRI values in multiple regions, including the fusiform gyrus and cerebellum.
Conclusion: Structural and resting-state functional abnormalities in the brain may be useful imaging biomarkers for identifying alterations in trauma-exposed firefighters without PTSD.
키워드
Brain; Firefighters; Magnetic Resonance Imaging; Stress Disorder, Post-Traumatic
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