ÆæŸ´Ò øÆ÷ ³²¿ëÀ¸·Î ÀÎÇÑ Áö¿¬¼º Àú»ê¼Ò¼º ¹é»öÁú³úÁõ: Áõ·Ê º¸°í
Delayed Post-Hypoxic Leukoencephalopathy Induced by an Overdose with Fentanyl Patches: A Case Report
ÃÖÁø¼Ö, À¯Àº¾Ö, ÃÖÁø¿Á, ±è¼öÁ¤,
¼Ò¼Ó »ó¼¼Á¤º¸
ÃÖÁø¼Ö ( Choi Jin-Sol )
Presbyterian Medical Center Department of Radiology
À¯Àº¾Ö ( Yoo Eun-Ae )
Presbyterian Medical Center Department of Radiology
ÃÖÁø¿Á ( Choi Jin-Ok )
Presbyterian Medical Center Department of Radiology
±è¼öÁ¤ ( Kim Soo-Jung )
Presbyterian Medical Center Department of Radiology
Abstract
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Fentanyl intoxication has occasionally been reported since fentanyl patches became available for medical use. Delayed post-hypoxic leukoencephalopathy is a complication of hypoxia. However, its neuropsychiatric symptoms can be delayed, and it can progress to leukoencephalopathy even after full recovery from coma due to acute intoxication. Herein, we report a case of fentanyl intoxication in a 65-year-old man who was presented to the hospital because of unconsciousness for 13 hours after using ten fentanyl patches simultaneously. Initial brain CT findings were non-specific. Twenty days later, delayed neuropathologic symptoms manifested, and MRI showed bilaterally symmetrical, heterogeneous, confluent high signal intensities on T2-weighted/fluid attenuated inversion recovery MRI in the cerebral white matter with diffusion restriction. This was followed by rapid exacerbation of neuropathological symptoms with diffuse severe cerebral atrophy over 1 year.
Å°¿öµå
Leukoencephalopathies; Fentanyl; Drug Overdose
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