Clinical and Imaging Findings of Neonatal Seizures Presenting as Diffuse Cerebral White Matter Abnormality on Diffusion-Weighted Imaging without any Structural or Metabolic Etiology
김매란, 황재연, 이연주, 김용우, 변신연, 이윤진, 염정아, 전웅배, 추기석, 남경진, Reid Storm Nicholas Shaun,
소속 상세정보
김매란 ( Kim Mae-Ran )
Pusan National University Yangsan Hospital Department of Radiology
황재연 ( Hwang Jae-Yeon )
Pusan National University Yangsan Hospital Department of Radiology
이연주 ( Lee Yeoun-Joo )
Pusan National University School of Medicine Pusan National University Children’s Hospital Department of Pediatrics
김용우 ( Kim Yong-Woo )
Pusan National University Yangsan Hospital Department of Radiology
변신연 ( Byun Shin-Yun )
Pusan National University School of Medicine Pusan National University Children’s Hospital Department of Pediatrics
이윤진 ( Lee Yun-Jin )
Pusan National University School of Medicine Pusan National University Children’s Hospital Department of Pediatrics
염정아 ( Yeom Jeong-A )
Pusan National University Yangsan Hospital Department of Radiology
전웅배 ( Jeon Ung-Bae )
Pusan National University Yangsan Hospital Department of Radiology
추기석 ( Choo Ki-Seok )
Pusan National University Yangsan Hospital Department of Radiology
남경진 ( Nam Kyung-Jin )
Pusan National University Yangsan Hospital Department of Radiology
( Reid Storm Nicholas Shaun )
Kyungsung University School of Liberal Arts Education College of Creative Human Resource
Abstract
Purpose: Some patients with neonatal seizures show diffuse, symmetric diffusion-restricted lesions in the cerebral white matter. The aim of this study was to describe clinical and imaging findings of patients with neonatal seizures who had diffuse, symmetric diffusion-restricted lesions without any structural or metabolic etiology.
Materials and Methods: A total of 56 neonates aged less than 1 week underwent brain magnetic resonance imaging (MRI) for evaluation of seizures from November 2008 to February 2017. After excluding 43 patients, 13 patients showed diffuse white matter abnormality on diffusion-weighted imaging. Initial and follow-up clinical and MRI findings were analyzed retrospectively.
Results: All 13 patients were born at full term. Among the ten patients who underwent a stool test for viruses, six were positive for rotavirus and one for astrovirus. MRI revealed diffuse, symmetric diffusion-restricted lesions distributed along the cerebral white matter, thalami, and midbrain variably.
Conclusion: Diffuse, symmetric diffusion-restricted lesions involving the cerebral white matter can be seen in patients with neonatal seizures without any structural or metabolic etiology. Rotavirus is commonly but not exclusively detected in these patients. Nevertheless, viral infection-associated encephalopathy should be considered for patients with characteristic clinical and MRI findings.
키워드
Infant; Newborn; Rotavirus; Diffusion Magnetic Resonance Imaging
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