A Novel Anthropometric Parameter, Weight-Adjusted Waist Index Represents Sarcopenic Obesity in Newly Diagnosed Type 2 Diabetes Mellitus
박민정, 황순영, 김남훈, 김신곤, 최경묵, 백세현, 유혜진,
소속 상세정보
박민정 ( Park Min-Jeong )
황순영 ( Hwang Soon-Young )
김남훈 ( Kim Nam-Hoon )
Korea University College of Medicine Department of Internal Medicine Division of Endocrinology and Metabolism
김신곤 ( Kim Sin-Gon )
Korea University College of Medicine Department of Internal Medicine Division of Endocrinology and Metabolism
최경묵 ( Choi Kyung-Mook )
Korea University College of Medicine Department of Internal Medicine Division of Endocrinology and Metabolism
백세현 ( Baik Sei-Hyun )
Korea University College of Medicine Department of Internal Medicine Division of Endocrinology and Metabolism
유혜진 ( Yoo Hye-Jin )
Korea University College of Medicine Department of Internal Medicine Division of Endocrinology and Metabolism
Abstract
Background: As the metabolic significance of sarcopenic obesity (SO) is revealed, finding an appropriate index to detect SO is important, especially for type 2 diabetes mellitus (T2DM) patients with accompanying metabolic dysfunction.
Methods: Participants (n=515) from the Korea Guro Diabetes Program were included to compare how well waist circumference (WC), waist hip ratio (WHR), waist height ratio (WHtR), and the weight-adjusted waist index (WWI) predict SO in newly diagnosed T2DM patients. Sarcopenia was defined based on guidelines from the 2019 Asian Working Group for Sarcopenia as both low muscle mass (appendicular skeletal muscle [ASM]/height2 <7.0 kg/m2 for men, <5.4 kg/m2 for women) and strength (handgrip strength <28.0 kg for men, <18.0 kg for women) and/or reduced physical performance (gait speed <1.0 m/sec). Obesity was defined as a WC ≥90 cm in men and ≥85 cm in women. The WHR, WHtR, and WWI were calculated by dividing the WC by the hip circumference, height, and √ weight, respectively.
Results: The WC, WHR, and WHtR correlated positively with the fat and muscle mass represented by truncal fat amount (TFA) and ASM, whereas the WWI was proportional to the TFA and inversely related to ASM. Of the four indices, the WWI showed the highest area under the receiver operative characteristic curve for SO. The WWI also exhibited a positive correlation with albuminuria and the mean brachial-ankle pulse wave velocity, especially in patients aged ≥65 years.
Conclusion: The WWI is the preferable anthropometric index for predicting SO in T2DM patients, and it might be a proper index for predicting cardiometabolic risk factors in elderly people.
키워드
Type2 diabetes mellitus; Sarcopenic obesity; Anthropometric index
원문 및 링크아웃 정보
등재저널 정보