Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy
Kristinsson Sigfus, den Ouden Dirk B., Rorden Chris, Newman-Norlund Roger, Neils-Strunjas Jean, Fridriksson Julius,
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( Kristinsson Sigfus )
University of South Carolina Center for the Study of Aphasia Recovery
( den Ouden Dirk B. )
University of South Carolina Center for the Study of Aphasia Recovery
( Rorden Chris )
University of South Carolina Center for the Study of Aphasia Recovery
( Newman-Norlund Roger )
University of South Carolina Center for the Study of Aphasia Recovery
( Neils-Strunjas Jean )
University of South Carolina Department of Communication Sciences and Disorders
( Fridriksson Julius )
University of South Carolina Center for the Study of Aphasia Recovery
Abstract
Chronic aphasia, a devastating impairment of language, affects up to a third of stroke survivors. Speech and language therapy has consistently been shown to improve language function in prior clinical trials, but few clinicially applicable predictors of individual therapy response have been identified to date. Consequently, clinicians struggle substantially with prognostication in the clinical management of aphasia. A rising prevalence of aphasia, in particular in younger populations, has emphasized the increasing demand for a personalized approach to aphasia therapy, that is, therapy aimed at maximizing language recovery of each individual with reference to evidence-based clinical recommendations. In this narrative review, we discuss the current state of the literature with respect to commonly studied predictors of therapy response in aphasia. In particular, we focus our discussion on biographical, neuropsychological, and neurobiological predictors, and emphasize limitations of the literature, summarize consistent findings, and consider how the research field can better support the development of personalized aphasia therapy. In conclusion, a review of the literature indicates that future research efforts should aim to recruit larger samples of people with aphasia, including by establishing multisite aphasia research centers.
키워드
Stroke; Aphasia; Language therapy
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