Molecular imaging of atherosclerosis using reporter gene system
유란지, 이교철, 강주현, 이용진,
소속 상세정보
유란지 ( Yoo Ran-Ji )
Korea Institute of Radiological and Medical Sciences Department of RI-Convergence Research
이교철 ( Lee Kyo-Chul )
Korea Institute of Radiological and Medical Sciences Department of RI-Convergence Research
강주현 ( Kang Joo-Hyun )
Korea Institute of Radiological and Medical Sciences Department of RI-Convergence Research
이용진 ( Lee Yong-Jin )
Korea Institute of Radiological and Medical Sciences Department of RI-Convergence Research
Abstract
Macrophages play a key role in atherosclerotic plaque formation, but their participation has been discerned largely via ex vivo analyses of atherosclerotic lesions. Therefore, we aimed to identify atherosclerosis on noninvasive in vivo imaging using reporter gene system. This study demonstrated that recruitment of macrophages could be detected in atherosclerotic plaques of Apolipoprotein E knockout (ApoE-/-) mice with a sodium iodide symporter (NIS) gene imaging system using 99mTc-SPECT. This novel approach to tracking macrophages to atherosclerotic plaques in vivo could have applications in studies of arteriosclerotic vascular disease.
키워드
Atherosclerosis; Click chemistry; Macrophage; Reporter gene; SPECT imaging; PET imaging
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