Preparation of iron oxide nanoparticle combined with radioisotope for molecular imaging
박지용, 이윤상, 정재민,
소속 상세정보
박지용 ( Park Ji-Yong )
Seoul National University College of Medicine Department of Nuclear Medicine
이윤상 ( Lee Yun-Sang )
Seoul National University Hospital Department of Nuclear Medicine
정재민 ( Jeong Jae-Min )
Seoul National University College of Medicine Department of Nuclear Medicine
Abstract
Molecular imaging refers to detect the biochemical process in living organisms at the cellular and molecular levels and to quantify them. Due to several advantages of nanomaterials, various molecular images using nanomaterials are being tried. Attempts have been made to combine nanoparticles, known as micro- or nanosized nanomaterials, with radioactive isotopes for molecular imaging probe. The radiolabeled nanoparticles will expend the molecular imaging due to nanoparticle's size-dependent nature. In particular, iron oxide nanoparticles can be used for magnetic resonance imaging, can be adjusted in size, easily functionalized, and biocompatible, making it a very good platform for molecular imaging. In addition, iron oxide nanoparticles may be the best example for a new approach to molecular imaging techniques. In this paper, we introduce various methods for preparation of iron oxide nanoparticle combined with radioisotope starting from various synthesis methods of iron oxide nanoparticles to utilize iron oxide nanoparticles as a platform for molecular imaging through radioactive labeling.
키워드
Nanoparticle; Radioisotope; Labeling method; PET; MRI
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