Synthesis of oleyl-4[131I]-iodobenzoate for long-term cell trafficking
전학림, 이웅희, 오지은, 이용진, 유정수,
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전학림 ( Jeon Hak-Rim )
Kyungpook National University School of Medicine Department of Molecular Medicine
이웅희 ( Lee Woong-Hee )
Kyungpook National University School of Medicine Department of Molecular Medicine
오지은 ( Oh Ji-Eun )
Kyungpook National University School of Medicine Department of Molecular Medicine
이용진 ( Lee Yong-Jin )
Korea Institute of Radiological and Medical Sciences Department of RI-Convergence Research
유정수 ( Yoo Jeong-Soo )
Kyungpook National University School of Medicine Department of Molecular Medicine
Abstract
Great efforts are currently devoted to the development of new approaches for the labeling of cells using appropriate radionuclides. While fluoride-18 and copper-64 have been extensively studied as short-term and intermediate-term trafficking agents, iodide was studied less intensely. Here, we report a new cell labeling agent labeled with 131I , [131I]oleyl-4-iodobenzoate ([131I]OIB) for long-term cell trafficking. A precursor of [131I]OIB was obtained in two steps, with the yield of 35%. The radiochemical yield of [131I]OIB was over 50%. While [131I] OIB could label different cells, L6 cells showed the highest cell-labeling efficiency. The [131I]OIB-labeled L6 cells were imprinted into a rat heart, and then monitored noninvasively for 2 weeks by gamma camera imaging. We conclude that [131I]OIB is a good candidate molecule for a long-term cell trafficking agent.
키워드
Radiotracer ; Cell trafficking agent; I-131 ; Gamma camera imaging
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