Aliphatic radiofluorination using TBAHCO3 eluate in hydrous organic medium
권영도, 손정민, 전중현,
소속 상세정보
권영도 ( Kwon Young-Do )
Yonsei University College of Medicine Department of Nuclear Medicine
손정민 ( Son Jeong-Min )
Yonsei University Health System Severance Hospital Department of Nuclear Medicine
전중현 ( Chun Joong-Hyun )
Yonsei University College of Medicine Department of Nuclear Medicine
Abstract
Azeotropic drying process is routinely applied to enhance nucleophilicity of [18F]fluoride ion during the nucleophilic production of PET radiotracers; however, the drying process requires usually 15?25 min. Due to the high demand of employing fluorine-18 (t1/2 = 109.8 min) in PET radiopharmaceutical production, several research groups have focused on the method development, obviating tedious removal process of the residual target water ([18O]H2O) for [18F]fluoride ion complex to be used in radiofluorination. Some development in radiofluorination in a mixed organic solvent system was demonstrated with various aliphatic substrates, but only kryptand as a phase transfer agent was utilized in the reported method. Here, we extend to investigate the development scope of applicability with basic alkyl ammonium salt as a phase transfer agent through the extensive elution efficiency study and radiofluorination outcome for aliphatic radiofluorination
키워드
Fluorine-18; Radiofluorination; Phase transfer agent; Radiotracer; PET
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