Assessment of chemical purity of [13N]ammonia injection: Identification of aluminium ion concentration
김호영, 박종범, 이지연, 이윤상, 정재민,
소속 상세정보
김호영 ( Kim Ho-Young )
Seoul National University College of Medicine Department of Nuclear Medicine
박종범 ( Park Jong-Bum )
Seoul National University Hospital Department of Nuclear Medicine
이지연 ( Lee Ji-Youn )
Seoul National University College of Medicine Department of Nuclear Medicine
이윤상 ( Lee Yun-Sang )
Seoul National University College of Medicine Department of Nuclear Medicine
정재민 ( Jeong Jae-Min )
Seoul National University College of Medicine Department of Nuclear Medicine
Abstract
13N]Ammonia or [13N]NH3 is one of the most widely used PET tracer for the measurement of MBF. To produce [13N]NH3, devarda’s alloy which contains aluminum, copper and zinc is used for the purpose of reduction from 13N-nitrate/nitrite to [13N]NH3. Since aluminum has neurotoxicity and renal toxicity, the amount of it should be carefully limited for the administration to the human body. Although USP and EP provide a way to identify the aluminum ion concentration, there are some difficulties to perform. Therefore, we tried to develop the modified method for verifying aluminum concentration of test solution. We compared color between test and standard solutions using chrome azurol S in pH 4.6 acetate buffer. We also tested color change of test and standard solutions according to pH, amounts and the order of reagent and time difference These results demonstrated that the color change of the solution can reflect quantitatively measure aluminum ion concentration. We hope the method is to be used effectively and practically in many sites where [13N]NH3 is produced.
키워드
[13N]NH3; Quality control; Aluminum test; Devarda’s alloy; chrome azurol S
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