The radioligands with VEGF121 for angiogenesis of tumor
Yim Min-Su, 류은경,
소속 상세정보
( Yim Min-Su )
Korea Basic Science Institute Division of Bioconvergence Analysis
류은경 ( Ryu Eun-Kyoung )
Korea Basic Science Institute Division of Bioconvergence Analysis
Abstract
Angiogenesis is the new blood vessel formation process and has known to a fundamental event of tumor growth and metastasis. Especially, vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFRs) are the crucial regulators of angiogenesis in tumor. VEGF-A is one of the VEGF family and binds to endothelial cell specific VEGFR1 and VEGFR2, which are associated with tumor growth and tumor angiogenesis. VEGF121 is more tumorigenic isomer of VEGF-A. Targeted VEGF or VEGFR molecular imaging has been widely used to enable diagnosis and monitoring of proliferation and development of angiogenic tumors. Therefore, in this review, we have focused on the radioligands with VEGF121 for angiogenesis of tumor.
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원문 및 링크아웃 정보
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