Radiolabeled 2D graphitic nanomaterials and their possibility for molecular imaging applications
강석민, 김철희, 김동욱,
소속 상세정보
강석민 ( Kang Seok-Min )
Inha University Department of Chemistry and Chemical Engineering
김철희 ( Kim Chul-Hee )
Inha University Department of Chemistry and Chemical Engineering
김동욱 ( Kim Dong-Wook )
Inha University Department of Chemistry and Chemical Engineering
Abstract
In recent years, many researchers have attempted to make use of 2D nanoparticles as molecular imaging probes since extensive investigations proved that 2D nanoparticles in the body tends to accumulate certain lesions by enhanced permeability and retention (EPR) effect. For example, graphene and carbon nitride which have high surface area and modifiable properties showed good biocompatibility and targetability when it used as imaging probes. However, poor dispersibility in physiological mediums and its uncontrolled size limited its usage in bio-application. Therefore, oxidation process and mechanical exfoliation have been developed for overcoming these problems. In this paper, we highlight the several major methods to synthesize biocompatible 2D nanomaterials like graphene and carbon nitride especially for molecular imaging study including positron emission tomography (PET).
키워드
2D nanomaterial; Graphene; Carbon nitride; Positron emission tomography; Molecular imaging probes; Exfoliation
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