청색광 흡수 고분자 소재 합성 및 콘택트렌즈 제조
Synthesizing of Blue-light Blocking Polymeric Materials and Manufacturing Contact Lenses
유근창, 이철우, 서은선,
소속 상세정보
유근창 ( Ryu Geun-Chang )
Dongshin University Department of Optometry and Optic Science
이철우 ( Lee Cheol-Woo )
Dongshin University Department of Optometry and Optic Science
서은선 ( Seo Eun-Sun )
Dongshin University Department of Optometry and Optic Science
Abstract
Purpose : Blue-light blocking polymers were synthesized and interpenetrated into the hydrogel contact lenses. The water contents and blue-light blocking properties of the resultant contact lenses with varying amounts of the blue-light blocking polymers were investigated and compared to that of the unmodified control.
Methods : Polyethyleneimine (PEI) was covalently conjugated with blue-light adsorbing reactive dyes (Procion Yellow MX8G) via a nucleophilic substitution reaction and incorporated into the hydrogel contact lenses. The blue-light blocking properties of the hydrogel lenses were investigated using UV-vis spectrophotometry.
Results : The blue-light adsorbing reactive dyes were successfully conjugated to the PEI and well incorporated into the hydrogel contact lenses. The resultant contact lenses exhibited good blue-light blocking properties according to the results of the UV-vis spectra investigation. Furthermore, we confirmed that the blue-light adsorbing dyes were not eluted from the contact lenses after extensive washings for 3 days.
Conclusion : This report describes the synthesis and characterization of a series of hydrogel contact lenses containing blue-light blocking polymers. The hydrogel contact lenses showed good water contents and a transmittance of over 90% in the range of 450~700 nm. In particular, the blue-light blocking properties at the range of 380~450 nm were enhanced significantly as the increment in the amount of incorporated blue-light blocking polymers. The preparation of blue-light-blocking contact lenses may offer a new opportunity for the development of biomedical ophthalmic devices.
키워드
Blue-light; Contact Lens; Hydrogel; Polyethyleneimine; Reactive dyes
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