한국 성인 남성 중 과거 흡연자에서 흡연 당시의 흡연 행태 및 금연 기간과 고감도 C-반응 단백과의 연관성 : 국민건강영양조사 자료를 이용
Correlation of Past Smoking Behaviors and Duration of Smoking Cessation with High-sensitivity C-reactive Protein Among Past Smokers in Korean Male Adults : Korean National Health and Nutrition Examination Survey
손용호, 함상근, 박진아, 신민우, 유은혜, 정지영, 오민석, 이승주, 임재형,
소속 상세정보
손용호 ( Sohn Yong-Ho )
한일병원 가정의학과
함상근 ( Hahm Sang-Keun )
한일병원 가정의학과
박진아 ( Park Jin-A )
한일병원 가정의학과
신민우 ( Shin Min-Woo )
한일병원 가정의학과
유은혜 ( Yu Eun-Hye )
한일병원 가정의학과
정지영 ( Jung Ji-Young )
한일병원 가정의학과
오민석 ( Oh Min-Seok )
한일병원 가정의학과
이승주 ( Lee Seung-Ju )
한일병원 가정의학과
임재형 ( Rhim Jae-Hyung )
한일병원 가정의학과
Abstract
Background: C-reactive protein (CRP) can be used to assess the risk of cardiovascular disease. Previous studies have demonstrated the relationship between cigarette smoking and high-sensitivity CRP (hs-CRP) elevation. However, the effects of smoking cessation on hs-CRP have not been evaluated in Korean male adults.
Methods: Based on the Korean National Health and Nutrition Examination Survey of 2015-2016, self-reported former smokers were selected. Participants with laboratory test results suggesting acute inflammation or any history of conditions that could elevate CRP levels were excluded. The frequency of hs-CRP elevation was compared between groups with various past smoking behaviors and duration of smoking cessation.
Results: The total number of selected participants was 1,243. Participants with larger cumulative smoking amount (P=0.026) or shorter duration of smoking cessation (P=0.024) tended to have significantly higher frequency of hs-CRP elevation. By logistic regression analysis, larger cumulative smoking amount have shown higher probability of hs-CRP elevation than smaller amount, but with no statistical significance. Long-term (＞10 years) and mid-term (5-10 years) cessation have shown lower probability of hs-CRP elevation than short-term (＜5 years), with statistical significance only between short-term and long-term cessation (odds ratio 0.64; 95% confidence interval 0.41-0.98, P=0.038).
Conclusion: Among past smokers in Korean male adults, the frequency of hs-CRP level elevation tended to be higher with larger cumulative smoking amount or shorter duration of smoking cessation. The risk of hs-CRP elevation was significantly lower with long-term smoking cessation than short-term cessation.
키워드
Smoking cessation; C-reactive protein; Cardiovascular disease; Korean National Health and Nutrition Examination Survey
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